BDNF down-regulates the caspase 3 pathway in injured geniculo-cortical neurones. (Articolo in rivista)

Type
Label
  • BDNF down-regulates the caspase 3 pathway in injured geniculo-cortical neurones. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1097/00001756-200409150-00010 (literal)
Alternative label
  • Madeddu F, Naska S, Bozzi Y (2004)
    BDNF down-regulates the caspase 3 pathway in injured geniculo-cortical neurones.
    in NeuroReport (Oxf.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Madeddu F, Naska S, Bozzi Y (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • INCNR PISA (literal)
Titolo
  • BDNF down-regulates the caspase 3 pathway in injured geniculo-cortical neurones. (literal)
Abstract
  • Visual cortex ablation in newborn rats causes a rapid and almost complete degeneration of neurones in the dorsal lateral geniculate nucleus (dLGN), as a consequence of the axotomy of geniculocortical fibres. Death of dLGN neurones occurs by apoptosis and is partially prevented (similar to50%) by intraocular delivery of brain-derived neurotrophic factor (BDNF). Here we investigated the molecular mechanisms of BDNF-mediated neuroprotection. We found that exogenous administration of BDNF partially decreases (similar to50%) the up-regulation of apoptotic proteins (phosphorylated c-Jun, cytochrome C and cleaved caspase 3), that occurs in dLGN neurones following visual cortex ablation at postnatal day 7 These results demonstrate that the neuroprotective action of BDNF on axotomised dLGN neurones involves the partial blockade of well-characterised apoptotic pathways. (literal)
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