Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00726-004-0142-0 (literal)

Alternative label

• Cacciatore I.,Cocco A., Costa M., Fontana M., Lucente G., Pecci L., Pinnen F. (2005)
  Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation.
  in Amino acids (Wien, Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cacciatore I.,Cocco A., Costa M., Fontana M., Lucente G., Pecci L., Pinnen F. (literal)

Pagina inizio

• 77 (literal)

Pagina fine

• 83 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 28 (literal)

Rivista

• Amino acids (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ G DAnnuzio, Dipartimento Sci Farmaco, I-66013 Chieti, Italy Univ Roma La Sapienza, Dipartimento Studi Farmaceutici, Rome, Italy Univ Roma La Sapienza, Dipartimento Sci Biochim, Rome, Italy Univ Roma La Sapienza, CNR, Ist Biol & Patol Mol, Rome, Italy (literal)

Titolo

• Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation. (literal)

Abstract

• Three novel carnosine analogues 7-9 containing the residue of L(+)2,3-diaminopropionic acid with different degree of N-acetylation instead of beta-alanine have been synthesized and characterized. Comparative analysis of hydrolysis by carnosinase revealed that the mono- and bis-acetylated compounds 8 and 9 are resistant to enzymatic hydrolysis and act as competitive inhibitors of this enzyme. The hydroxyl radical scavenging potential of the three analogues was evaluated by their ability to inhibit iron/H2O2-induced degradation of deoxyribose. The second-order rate constants of the reaction of compounds 7-9 with hydroxyl radical were almost identical to that of carnosine. These compounds were also found to act as protective agents against peroxynitrite-dependent damage as assessed by their ability to prevent nitration of free tyrosine induced by this species. (literal)

Prodotto di

• Biologia strutturale e bioinformatica: struttura-funzione, dinamica e riconoscimento in proteine (SV.P14.008.001) (Modulo)
• Sintesi di nuovi farmaci per malattie neurodegenerative (PM.P01.010.002) (Modulo)
• Istituto di chimica biomolecolare (ICB) (Istituto)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• Gino Lucente (Persona)
• Laura Pecci (Persona)

Insieme di parole chiave

• Keywords of "Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Istituto di chimica biomolecolare (ICB) (Istituto)
• Sintesi di nuovi farmaci per malattie neurodegenerative (PM.P01.010.002) (Modulo)
• Biologia strutturale e bioinformatica: struttura-funzione, dinamica e riconoscimento in proteine (SV.P14.008.001) (Modulo)

Autore CNR di

• Gino Lucente (Persona)
• Laura Pecci (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Amino acids (Rivista)

Insieme di parole chiave di

• Keywords of "Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation." (Insieme di parole chiave)