Identification of cross-reactive and genuine Parietaria judaica pollen allergens (Articolo in rivista)

Type
Label
  • Identification of cross-reactive and genuine Parietaria judaica pollen allergens (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Stumvolla S *, PhD, Westritschniga K, MD, Lidholmb J, PhD, Spitzauerc S, MD,Colombo P, MD, Duro G, MD, Krafta D. , MD, Geraci D., PhD, and Valentaa R. (2003)
    Identification of cross-reactive and genuine Parietaria judaica pollen allergens
    in Journal of allergy and clinical immunology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Stumvolla S *, PhD, Westritschniga K, MD, Lidholmb J, PhD, Spitzauerc S, MD,Colombo P, MD, Duro G, MD, Krafta D. , MD, Geraci D., PhD, and Valentaa R. (literal)
Pagina inizio
  • 974 (literal)
Pagina fine
  • 979 (literal)
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  • 111 (literal)
Rivista
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  • Impact Factor: 5.560 (literal)
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  • I dati riportati in questo lavoro descrivono, per la prima volta, l'importanza dell'allergene Parj2, da noi in precedenza isolato e caratterizzato (Duro et al. FEBS 1996), nella diagnosi dell'allergia al polline di Parietaria. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • Department of Pathophysiology, AKH, University of Vienna, Vienna, Austria e Istituto di Biomedicina e di Immunologia Molecolare del CNR di Palermo (literal)
Titolo
  • Identification of cross-reactive and genuine Parietaria judaica pollen allergens (literal)
Abstract
  • The weed Parietaria judaica is one of the most important pollen allergen sources in the Mediterranean area. OBJECTIVE: We sought to identify P judaica pollen allergen, which might be used to serologically distinguish genuine Parietaria sensitization and cross-reactivity to allergens from other weed species (eg, mugwort and ragweed). METHODS: The allergen profile of P judaica IgE-reactive sera from weed pollen-sensitized allergic individuals from the Mediterranean region (n = 36) with high Parietaria pollen exposure and from weed pollen-allergic patients with little or no Parietaria exposure (Austria, n = 42; Scandinavia, n = 8; United States, n = 19) was established by CAP FEIA measurements and by IgE immunoblot inhibition experiments with recombinant allergens. RESULTS: The majority (83%) of the Mediterranean weed pollen-allergic patients mounted high IgE antibody levels (mean specific IgE, 20.89 kUA/L) against recombinant (r) Par j 2, whereas only 7% of the non-Mediterranean weed-allergic patients showed low IgE reactivity to rPar j 2 (mean specific IgE, 1.03 kUA/L). The cytoskeletal protein profilin and a 2-EF-hand calcium-binding allergen were identified as cross-reactive Parietaria allergens, which were recognized preferentially by Parietaria -positive, non-Mediterranean weed pollen-allergic patients. CONCLUSION: rPar j 2 might be used as a diagnostic marker allergen to identify weed pollen-allergic patients who are genuinely sensitized against Parietaria pollen and thus would be particularly suited for specific immunotherapy with Parietaria pollen extract. (literal)
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