In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case of Organometallic Anticancer Drugs Not Based on Ruthenium (Articolo in rivista)

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  • In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case of Organometallic Anticancer Drugs Not Based on Ruthenium (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/om060394o (literal)
Alternative label
  • Dorcier, Antoine; Ang, Wee H.; Bolaño, Sandra; Gonsalvi, Luca; Juillerat-Jeannerat, Lucienne; Laurenczy, Gabor; Peruzzini, Maurizio; Phillips, Andrew D.; Zanobini, Fabrizio; Dyson, Paul J. (2006)
    In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case of Organometallic Anticancer Drugs Not Based on Ruthenium
    in Organometallics (Online); ACS, American chemical society, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Dorcier, Antoine; Ang, Wee H.; Bolaño, Sandra; Gonsalvi, Luca; Juillerat-Jeannerat, Lucienne; Laurenczy, Gabor; Peruzzini, Maurizio; Phillips, Andrew D.; Zanobini, Fabrizio; Dyson, Paul J. (literal)
Pagina inizio
  • 4090 (literal)
Pagina fine
  • 4096 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://pubs.acs.org/doi/abs/10.1021/om060394o (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 25 (literal)
Rivista
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  • 7 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland, University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), CH-1011 Lausanne, Switzerland (literal)
Titolo
  • In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case of Organometallic Anticancer Drugs Not Based on Ruthenium (literal)
Abstract
  • Reaction of the dimer [(eta5-C5Me5)RhCl(?2-Cl)]2 with 2 or 4 equiv of the water-soluble phosphine 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) affords [Rh(eta5-C5Me5)(pta)Cl2] and [Rh(eta5-C5Me5)(pta)2Cl]Cl, respectively. Both complexes have been characterized in solution by NMR spectroscopy and in the solid state by single-crystal X-ray diffraction, the latter as the chloride and BPh4- salts. In addition, the rhodium(I) complexes [Rh(eta5-C5Me5)(CO)(pta)] and [Rh(eta5-C5H5)(pta)2] have been prepared from [Rh(eta5-C5Me5)(CO)2] and [Rh(eta5-C5H5)(PPh3)2], respectively, by reaction with pta. An in vitro evaluation of these compounds, together with [Os(eta6-C10H14)(pta)Cl2] and the well-characterized antimetastasis drug [Ru(eta6-C10H14)(pta)Cl2], RAPTA-C, was undertaken using HT29 colon carcinoma, A549 lung carcinoma, and T47D breast carcinoma cells. In the HT29 cell line, the two nearest congeners to [Ru(eta6-C10H14)(pta)Cl2], viz., [Rh(eta5-C5Me5)(pta)Cl2] and [Os(eta6-C10H14)(pta)Cl2], demonstrated very similar cytotoxicity profiles. [Rh(eta5-C5Me5)(pta)Cl2] proved significantly more cytotoxic in A549 cells and [Rh(eta5-C5Me5)(pta)2Cl]Cl 3-fold more cytotoxic in T47D cells, both relative to RAPTA-C. These data suggest that the development of organometallic anticancer drugs based on the neighboring elements to ruthenium should not be overlooked. (literal)
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