http://www.cnr.it/ontology/cnr/individuo/prodotto/ID16626

Stereoselective Synthesis of Dienylamines: from Amino Acids to E-Alkene-Dipeptide Isosters (Articolo in rivista)

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Stereoselective Synthesis of Dienylamines: from Amino Acids to E-Alkene-Dipeptide Isosters (Articolo in rivista) (literal)

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Alternative label

Reginato, Gianna; Gaggini, Francesca; Mordini, Alessandro; Valacchi, Michela (2005)
Stereoselective Synthesis of Dienylamines: from Amino Acids to E-Alkene-Dipeptide Isosters
in Tetrahedron (Oxf., Print); Elsevier, Oxford (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Reginato, Gianna; Gaggini, Francesca; Mordini, Alessandro; Valacchi, Michela (literal)

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CNR ICCOM-Istituto di Chimica dei Composti Organometallici Dipartimento di Chimica Organica 'U. Schiff' Università di Firenze Via della Lastruccia 13 I 50019 Sesto Fiorentino italy (literal)

Titolo

Stereoselective Synthesis of Dienylamines: from Amino Acids to E-Alkene-Dipeptide Isosters (literal)

Abstract

A stereoselective approach to dienylamines is described, starting from enantiomerically enriched stannylated allylamines, which are in turn derived from amino acids. Conveniently the procedure allows to introduce diversity at 1-,2- and 4- positions of the final compounds. Conversion to vinylstannane has been extended to dipeptido aldehydes. The possible elaboration of 4-methyl substituted dienylamines to Boc-Gly-?[(E)-CHCH]-(l,d)-Ala and Boc-Phe -?[(E)-CHCH]-(l,d)-Ala dipeptide isosters is also shown. (literal)

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