Glycoclusters presenting lactose on calix[4]arene cores display trypanocidal activity. (Articolo in rivista)

Type
Label
  • Glycoclusters presenting lactose on calix[4]arene cores display trypanocidal activity. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.tet.2011.06.065 (literal)
Alternative label
  • E. Galante, C. Geraci, S. Sciuto, V. L. Campo, I. Carvalho, R. Sesti-Costa, P. M. M. Guedes, J. S. Silva, L. Hill, S. A. Nepogodiev, R. A. Field (2011)
    Glycoclusters presenting lactose on calix[4]arene cores display trypanocidal activity.
    in Tetrahedron (Oxf., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • E. Galante, C. Geraci, S. Sciuto, V. L. Campo, I. Carvalho, R. Sesti-Costa, P. M. M. Guedes, J. S. Silva, L. Hill, S. A. Nepogodiev, R. A. Field (literal)
Pagina inizio
  • 5902 (literal)
Pagina fine
  • 5912 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 67 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7 UH, UK Istituto di Chimica Biomolecolare, C.N.R., Via P. Gaifami, 18, I-95126, Italy Dipartimento di Scienze Chimiche, Università di Catania, Vile a. Doria 6, 95125 Catania, Italy Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Av. Café S/N, CEP 14040-903, Ribeirão Preto, SP, Brazil Faculdade de Medicina de Ribeirão Preto, USP, Av. Bandeirantes 3900, CEP 14049-900, Ribeirão Preto, SP, Brazil Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7 UH, UK (literal)
Titolo
  • Glycoclusters presenting lactose on calix[4]arene cores display trypanocidal activity. (literal)
Abstract
  • A new series of water-soluble tetravalent glycoclusters incorporating ?-lactosyl residues attached to a central calix[4]arene core was synthesised using azide-alkyne Cu(I)-catalysed cycloaddition (\"click chemistry\"). Carbohydrate moieties were attached either to upper or lower rim of rigid cone-shaped or partial cone macrocycles via 14-21 atom spacer arms. The glycoclusters with a C4-symmetrical arrangement of ?-lactosyl residues showed trypanocidal activity, with one of them showing comparable activity to established anti-trypanosomal drug benznidazole in in vitro anti-parasite assays. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it