Comparison of distance information in [TOAC(1), Glu(OMe)(7,18,19)] alamethicin F50/5 from paramagnetic relaxation enhancement measurements with data obtained from an X-ray diffraction-based model (Articolo in rivista)

Type
Label
  • Comparison of distance information in [TOAC(1), Glu(OMe)(7,18,19)] alamethicin F50/5 from paramagnetic relaxation enhancement measurements with data obtained from an X-ray diffraction-based model (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/psc.135 (literal)
Alternative label
  • Jose R.A., De Zotti M., Peggion C., Formaggio F., Toniolo C., De Borggraeve W.M. (2011)
    Comparison of distance information in [TOAC(1), Glu(OMe)(7,18,19)] alamethicin F50/5 from paramagnetic relaxation enhancement measurements with data obtained from an X-ray diffraction-based model
    in Journal of peptide science (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Jose R.A., De Zotti M., Peggion C., Formaggio F., Toniolo C., De Borggraeve W.M. (literal)
Pagina inizio
  • 377 (literal)
Pagina fine
  • 382 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Molecular Design and Synthesis, Department of Chemistry, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium; ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova, Italy (literal)
Titolo
  • Comparison of distance information in [TOAC(1), Glu(OMe)(7,18,19)] alamethicin F50/5 from paramagnetic relaxation enhancement measurements with data obtained from an X-ray diffraction-based model (literal)
Abstract
  • Peptaibol antibiotics are membrane-active linear peptides of fungal origin that are characterized by a high population of the C-alpha-tetrasubstituted, strongly helicogenic, alpha-amino acid, alpha-aminoisobutyric acid, an N-terminal acetyl group, and a C-terminal 1,2-amino alcohol. Alamethicins (Alms), among the longest peptaibiotics, are a group of closely sequence-related peptides composed of 19 amino acid residues. [TOAC(1), Glu(OMe)(7,18,19)] Alm and [TOAC(16), Glu(OMe)(7,18,19)] Alm are synthetic, nitroxide free-radical labeled analogs of [Glu(OMe)(7,18,19)] Alm F50/5. In this work, nitroxide to peptide NH proton distance information obtained from paramagnetic relaxation enhancement (PRE) studies on [TOAC(1), Glu(OMe)(7,18,19)] Alm is compared with distances derived from an X-ray diffraction-based model. The methodology for PRE determination, as well as the generation of the X-ray diffraction-based model three-dimensional structures, is discussed. The distances obtained from PRE measurements are in close agreement with the information derived from the X-ray diffraction-based model. This finding suggests that this type of information could be implemented as long-range distance restraints in NMR-based structure determination. (literal)
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