Risedronate metal complexes potentially active against Chagas disease (Articolo in rivista)

Type
Label
  • Risedronate metal complexes potentially active against Chagas disease (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jinorgbio.2010.08.004 (literal)
Alternative label
  • Demoro Bruno; Caruso Francesco; Rossi Miriam; Bentez Diego; Gonzalez Mercedes; Cerecetto Hugo; Parajon-Costa Beatriz; Castiglioni Jorge; Galizzi Melina; Docampo Roberto; Otero Luca ; Gambino Dinorah (2010)
    Risedronate metal complexes potentially active against Chagas disease
    in Journal of inorganic biochemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Demoro Bruno; Caruso Francesco; Rossi Miriam; Bentez Diego; Gonzalez Mercedes; Cerecetto Hugo; Parajon-Costa Beatriz; Castiglioni Jorge; Galizzi Melina; Docampo Roberto; Otero Luca ; Gambino Dinorah (literal)
Pagina inizio
  • 1252 (literal)
Pagina fine
  • 1258 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 104 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 12 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Cátedra de Química Inorgánica, DEC, Facultad de Química, Universidad de la República, Gral. Flores 2124, C. C. 1157, 11800 Montevideo, Uruguay; Istituto Chimica Biomolecolare, CNR, Ple. Aldo Moro, 5, 00185, Rome, Italy; Department of Chemistry, Vassar College, Poughkeepsie, NY 12604-0484, USA; Departamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo, Uruguay; Centro de Química Inorgánica (CEQUINOR/CONICET-UNLP), C.C. 962, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata, Argentina; LAFIDESU, DETEMA, Facultad de Química, Universidad de la República, Gral. Flores 2124, C. C. 1157, 11800 Montevideo, Uruguay; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, USA. (literal)
Titolo
  • Risedronate metal complexes potentially active against Chagas disease (literal)
Abstract
  • In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread Latin American parasitic disease, novel complexes of the bioactive ligand risedronate (Ris, (1-hydroxy-1- phosphono-2-pyridin-3-yl-ethyl)phosphonate), [MII(Ris)2]·4H2O, where M Cu, Co, Mn and Ni, and [NiII(Ris)2 (H2O)2]·H2O were synthesized and characterized by using analytical measurements, thermogravimetric analyses, cyclic voltammetry and infrared and Raman spectroscopies. Crystal structures of [CuII(Ris)2]·4H2O and [NiII(Ris)2(H2O)2]·H2O were solved by single crystal X-ray diffraction methods. The complexes, as well as the free ligand, were evaluated in vitro against epimastigotes and intracellular amastigotes of the parasite Trypanosoma cruzi, causative agent of Chagas disease. Results demonstrated that the coordination of risedronate to different metal ions improved the antiproliferative effect against T. cruzi, exhibiting growth inhibition values against the intracellular amastigotes ranging the low micromolar levels. In addition, this strong activity could be related to high inhibition of farnesyl diphosphate synthase enzyme. On the other hand, protein interaction studies showed that all the complexes strongly interact with albumin thus providing a suitable means of transporting them to tissues in vivo. (literal)
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