http://www.cnr.it/ontology/cnr/individuo/prodotto/ID15946
Main roads to melanoma (Articolo in rivista)
- Type
- Label
- Main roads to melanoma (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1186/1479-5876-7-86 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Palmieri G.; Capone M.E.; Ascierto M.L.; Gentilcore G.; Stroncek D.F.; Casula M.; Sini M.C.; Palla M.; Mozzillo N.; Ascierto P.A. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.translational-medicine.com/content/7/1/86 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche (CNR), Sassari, Italy; Istituto Nazionale Tumori \"Fondazione Pascale\", Napoli, Italy; Cell Processing Section, Department of Transfusion Medicine Clinical Center, NIH, Bethesda, MD, USA. (literal)
- Titolo
- Main roads to melanoma (literal)
- Abstract
- The characterization of the molecular mechanisms involved in development and progression of
melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical
behavior, and response to therapy as well as to better classify the subsets of melanoma patients
with different prognosis and/or clinical outcome. Actually, some aspects regarding the main
molecular changes responsible for the onset as well as the progression of melanoma toward a more
aggressive phenotype have been described. Genes and molecules which control either cell
proliferation, apoptosis, or cell senescence have been implicated. Here we provided an overview
of the main molecular changes underlying the pathogenesis of melanoma. All evidence clearly
indicates the existence of a complex molecular machinery that provides checks and balances in
normal melanocytes. Progression from normal melanocytes to malignant metastatic cells in
melanoma patients is the result of a combination of down- or up-regulation of various effectors
acting on different molecular pathways. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi