Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/jm900642j (literal)

Alternative label

• Paolo Ruzza; Antonio Rosato; Alberto Nassi; Maria Rondina; Matteo Zorzin; Carlo Riccardo Rossi; Maura Floreani; Luigi Quintieri (2009)
  Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent
  in Journal of medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Paolo Ruzza; Antonio Rosato; Alberto Nassi; Maria Rondina; Matteo Zorzin; Carlo Riccardo Rossi; Maura Floreani; Luigi Quintieri (literal)

Pagina inizio

• 4973 (literal)

Pagina fine

• 4976 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 52 (literal)

Rivista

• Journal of medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 15 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Chimica Biomolecolare del CNR, Sezione di Padova, via Marzolo 1, Padova, Italia; Dipartimento di Scienze Oncologiche e Chirurgiche, Universita di Padova, Padova, Italia, and Istituto Oncologico Veneto (IOV), IRCCS, via Gattamelata 64, Padova, Italia; Dipartimento di Farmacologia e Anestesiologia, Università di Padova, L.go Meneghetti 2, Padova, Italia. (literal)

Titolo

• Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent (literal)

Abstract

• We report the synthesis and preliminary in vitro biological evaluations of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a compound designed as a potential bifunctional antimelanoma agent, bearing both a tyrosinase-activa table phenolic moiety and a GSH-reactive alpha,beta-unsaturated carbonyl group. Both the E (1) and Z (2) isomers of the synthesized compound proved to be very good substrates of mushroom tyrosinase, reacted quickly with GSH at physiological pH, and showed a significant cytotoxic activity against B16F1 murine melanoma cells. (literal)

Prodotto di

• Peptidi internalizzanti (PM.P01.013.002) (Modulo)
• Istituto di chimica biomolecolare (ICB) (Istituto)

Autore CNR

• PAOLO RUZZA (Persona)

Insieme di parole chiave

• Parole chiave di "Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• PAOLO RUZZA (Persona)

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Peptidi internalizzanti (PM.P01.013.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of medicinal chemistry (Rivista)

Insieme di parole chiave di

• Parole chiave di "Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent" (Insieme di parole chiave)