2/4-Substituted-9-fluorenones and their O-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. Part 5 (Articolo in rivista)

Type
Label
  • 2/4-Substituted-9-fluorenones and their O-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. Part 5 (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ejmech.2008.01.045 (literal)
Alternative label
  • Adriana Arena; Nicoletta Arena; Rosella Ciurleo; Ambra de Gregorio; Rosanna Maccari; Rosaria Ottanà; Bernadette Pavone; Annabella Tramice; Antonio Trincone; Maria Gabriella Vigorita (2008)
    2/4-Substituted-9-fluorenones and their O-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. Part 5
    in European journal of medicinal chemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Adriana Arena; Nicoletta Arena; Rosella Ciurleo; Ambra de Gregorio; Rosanna Maccari; Rosaria Ottanà; Bernadette Pavone; Annabella Tramice; Antonio Trincone; Maria Gabriella Vigorita (literal)
Pagina inizio
  • 2656 (literal)
Pagina fine
  • 2664 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 43 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 12 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Discipline Chirurgiche, Sezione Microbiologia, Policlinico Universitario ''G. Martino'', 98123 Messina, Italy; Dipartimento di Chimica Organica e Biologica, Universita` di Messina, Salita Sperone 31, 98166 Messina, Italy; Dipartimento Farmaco-chimico, Universita` di Messina, Viale SS. Annunziata, 98168 Messina, Italy; Dipartimento Farmaco-biologico, Universita` di Messina, Viale SS. Annunziata, 98168 Messina, Italy; Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy (literal)
Titolo
  • 2/4-Substituted-9-fluorenones and their O-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. Part 5 (literal)
Abstract
  • In pursuing a research on the antiviral and immunomodulatory activity of tilorone congeners, two new series of compounds were prepared and pharmacologically explored: 9-fluorenone carboxyhydroxyesters, indicated as AG, and 9-fluorenone carboxyhydroxamides, indicated as MG. Two of them, AG17 and MG3, were used as sugar acceptors in the transglycosylation reactions performed by a- and b-glucosidases extracted from the marine mollusc Aplysia fasciata providing different a- and b-, mono- and oligosaccharides. Then aglycons and saccharides were assayed for cytotoxicity, for anti-herpes virus-2 properties on peripheral blood mononuclear cells (PBMC) and for their capability to trigger human cells to produce antiviral cytokines such as IFNa and TNFa. Some promising compounds were individuated whereas the utility of the biocatalytic procedures in the preparation of pure anomeric material was further focused. (literal)
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