Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease (Articolo in rivista)

Type
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  • Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.neuint.2007.06.031 (literal)
Alternative label
  • Tiziana Bisogno; Alberto Martire; Stefania Petrosino; Patrizia Popoli; Vincenzo Di Marzo; (2008)
    Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease
    in Neurochemistry international
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tiziana Bisogno; Alberto Martire; Stefania Petrosino; Patrizia Popoli; Vincenzo Di Marzo; (literal)
Pagina inizio
  • 307 (literal)
Pagina fine
  • 313 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://ac.els-cdn.com/S019701860700191X/1-s2.0-S019701860700191X-main.pdf?_tid=a8d6a40747ce18ce4635e497e9869255&acdnat=1335180771_e1c18535a8c04e915dda8d7affca593d (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 52 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1-2 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita` , Viale Regina Elena 299, 00161 Rome, Italy Dipartimento di Scienze Farmaceutiche, Universita` degli Studi di Salerno, Fisciano, Italy (literal)
Titolo
  • Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease (literal)
Abstract
  • Abstract Previous studies have shown an impairment of the endocannabinoid system in experimental models of Huntington's disease. In transgenic R6/ 2 mice, created by inserting exon 1 of the human IT15 mutant gene into the mouse, and exhibiting 150 CAG repeats as well as signs of HD, a progressive decline of CB1 receptor expression and an abnormal sensitivity to CB1 receptor stimulation have been reported. Here, by using isotope-dilution liquid chromatography-mass spectrometry, we investigated whether the levels of three endogenous neuroprotective substances, the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and palmitoylethanolamide (PEA), are altered in different brain areas of transgenic R6/2 versus wild-type (WT)mice at two different disease phases, i.e. in pre-symptomatic (4.5 weeks) or overtly symptomatic (10 weeks) R6/2 mice versus age-matched WT mice (n = 4/group). Except for a 25% decrease in 2-AG levels in the cortex, no significant changes in endocannabinoid and PEAlevelswere observed in pre-symptomaticR6/2 versusWTmice.By contrast, in symptomaticR6/2mice the levels of all three compounds were significantly (?30-60%) decreased in the striatum,whereas little changeswere observed in the hippocampus, and a ?28% decrease of 2-AG levels, accompanied by a ?50% increase of AEA levels, was found in the cortex. These findings show that endocannabinoid levels change in a disease phase- and region-specific way in the brain of R6/2 mice and indicate that an impaired endocannabinoid system is a hallmark of symptomatic HD, thus suggesting that drugs inhibiting endocannabinoid degradation might be used to treat this disease. (literal)
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