Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3390/molecules13040749 (literal)

Alternative label

• Urbani P.; Ramunno A.; Filosa R.; Pinto A.; Popolo A.; Bianchino E.; Piotto S.; Saturnino C.; De Prisco R.; Nicolaus B; Tommonaro G. (2008)
  Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis
  in Molecules (Basel, Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Urbani P.; Ramunno A.; Filosa R.; Pinto A.; Popolo A.; Bianchino E.; Piotto S.; Saturnino C.; De Prisco R.; Nicolaus B; Tommonaro G. (literal)

Pagina inizio

• 749 (literal)

Pagina fine

• 761 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 13 (literal)

Rivista

• Molecules (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Pharmaceutical Sciences, University of Salerno,Via Ponte don Melillo, 84084 Fisciano, (SA) Italy; Institute of Biomolecular Chemistry-CNR, Via Campi Flegrei 34, 80078 Pozzuoli, (NA) Italy (literal)

Titolo

• Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis (literal)

Abstract

• We report the synthesis, antioxidant and antiproliferative activity and a QSAR analysis of synthetic diphenylpropionamide derivatives. Synthesis of these compounds was achieved by direct condensation of 2,2- and 3,3-diphenylpropionic acid and appropriate amines using 1-propylphoshonic acid cyclic anhydride (PPAA) as catalyst. Compound structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in LPS stimulated J774.A1 macrophages. All compounds were tested for their effect on viability of cells and results demonstrated that they are not toxic towards the cell lines used. The cytotoxic activity of all compounds was evaluated by a Brine Shrimp Test. (literal)

Prodotto di

• DI DONATO- Le biomasse vegetali di scarto come fonte rinnovabile di molecole bioattive ed energia (PM.P01.008.002) (Modulo)
• Istituto di chimica biomolecolare (ICB) (Istituto)

Autore CNR

• GIUSEPPINA TOMMONARO (Persona)
• BARBARA NICOLAUS (Unità di personale interno)
• ROCCO DE PRISCO (Persona)

Insieme di parole chiave

• Keywords of "Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIUSEPPINA TOMMONARO (Persona)
• ROCCO DE PRISCO (Persona)
• BARBARA NICOLAUS (Unità di personale interno)

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• DI DONATO- Le biomasse vegetali di scarto come fonte rinnovabile di molecole bioattive ed energia (PM.P01.008.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecules (Rivista)

Insieme di parole chiave di

• Keywords of "Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis" (Insieme di parole chiave)