Hydroxytyrosol lipophilic analogues: enzymatic syntesis, radical scavering activity and DNA oxidative damage protection. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Hydroxytyrosol lipophilic analogues: enzymatic syntesis, radical scavering activity and DNA oxidative damage protection. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bioorg.2006.09.003 (literal)

Alternative label

• Grasso S.; Siracusa L.; Spatafora C.; Renis M.; Tringali C.. (2007)
  Hydroxytyrosol lipophilic analogues: enzymatic syntesis, radical scavering activity and DNA oxidative damage protection.
  in Bioorganic chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Grasso S.; Siracusa L.; Spatafora C.; Renis M.; Tringali C.. (literal)

Pagina inizio

• 137 (literal)

Pagina fine

• 152 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0045206806000794 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 35 (literal)

Rivista

• Bioorganic chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 16 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Chimica Biologica, Chimica Medica e Biologia Molecolare, Università di Catania, Viale A. Doria 6, IT-95125 Catania, Italy Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, IT-95125 Catania, Italy (literal)

Titolo

• Hydroxytyrosol lipophilic analogues: enzymatic syntesis, radical scavering activity and DNA oxidative damage protection. (literal)

Abstract

• The olive oil phenol hydroxytyrosol (3), as well its metabolite homovanillic alcohol (4), were subjected to chemoselective lipase-catalysed acylations, affording with good yield 10 derivatives (5-14) bearing C2, C3, C4, C10 and C18 acyl chains at C-1. Hydroxytyrosol (3) and its lipophilic derivatives showed very good DPPH radical scavenging activity. Compounds 3, 4 and their lipophilic analogues 5-14 were subjected to the atypical Comet test on whole blood cells: 3 and its analogues 5 and 6, with little hydrophobic character (log P ? 1.20), showed a good protective effect against H2O2 induced oxidative DNA damage. The homovanillic alcohol 4 and its analogues 10-14 resulted scarcely effective both as radical scavengers and antioxidant agents. (literal)

Prodotto di

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Definizione di metaboloma di piante a scopo applicativo (PM.P01.009.002) (Modulo)

Autore CNR

• LAURA SIRACUSA (Persona)

Insieme di parole chiave

• Keywords of "Hydroxytyrosol lipophilic analogues: enzymatic syntesis, radical scavering activity and DNA oxidative damage protection." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Definizione di metaboloma di piante a scopo applicativo (PM.P01.009.002) (Modulo)

Autore CNR di

• LAURA SIRACUSA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioorganic chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Hydroxytyrosol lipophilic analogues: enzymatic syntesis, radical scavering activity and DNA oxidative damage protection." (Insieme di parole chiave)