Identification of a probable new adrenergic agonist by nuclear magnetic resonance and mass spectrometry (Articolo in rivista)

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Label
  • Identification of a probable new adrenergic agonist by nuclear magnetic resonance and mass spectrometry (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.aca.2006.09.045 (literal)
Alternative label
  • G. Boatto; N. Culeddu; C. Testa; B. Neri; G. Brambilla; J. Barbosa; C. Cruz (2007)
    Identification of a probable new adrenergic agonist by nuclear magnetic resonance and mass spectrometry
    in Analytica chimica acta (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • G. Boatto; N. Culeddu; C. Testa; B. Neri; G. Brambilla; J. Barbosa; C. Cruz (literal)
Pagina inizio
  • 223 (literal)
Pagina fine
  • 227 (literal)
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  • Special issue; Selected and revised paper Conference: 5th International Symposium on Hormone and Veterinary Drug Residue Analysis, Location: Antwerp, BELGIUM Date: MAY 16-19, 2006 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 586 (literal)
Rivista
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  • 1-2 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Toxicological Chemistry, University of Sassari, Sassari, Italy; CNR Biomolecular Chemistry Institute, Sassari, Italy; IZS della Sardegna, Sassari, Italy; IZS delle Regioni Lazio e Toscana, Rome, Italy; Istituto Superiore di Sanità, Environment Department, Toxicological Chemistry Unit, Rome, Italy; LNIV, Lisbon, Portugal (literal)
Titolo
  • Identification of a probable new adrenergic agonist by nuclear magnetic resonance and mass spectrometry (literal)
Abstract
  • In animal production, it is consolidated the synthesis and the illegal use of growth promoters of new generation, able to skip routine screening and confirmatory analysis. In this work it is reported the nuclear magnetic resonance (NMR) and the mass spectrometry identification of a probable new adrenergic drug found in a feed premix. The substance was selectively purified on alpha 1 acid glycoprotein affinity columns; then its structure was first achieved by recording the 13C NMR spectrum that gave the total number of carbons of the molecule, successively sorted by DEPT experiments into quaternary, CH, CH2, and CH3 groups. However, the complete assignments of all resonances were derived from the bi-dimensional analysis and the crucial indications from the 1H-13C reverse experiments. Further characterisation was performed by atmospheric pressure chemical ionisation both in positive and negative ion mode, matching the molecular ion and the fragmentation pattern with those of most recently described new adrenergic agonists. After the loss of a ter-butylic group, the structure shows an internal symmetry along with the presence of Chlorine clusters. The proposed formula of the compound, the 8,8?-diamino-9,9?-dichloro-1-terbutyl-1,1?,4,4-tetrahydro-5H,5?H-2,2?-bi-1-benzazepine-5,5?-dione, partially resembles that of Zilpaterol for the presence of a heterocyclic ring; Further work is in progress to characterise the structure-activity relationship (literal)
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