Stereocontrolled Synthesis and Biological Activity of two Diastereoisomers of the Potent HIV-1 Protease Inhibitor Saquinavir (Articolo in rivista)

Type
Label
  • Stereocontrolled Synthesis and Biological Activity of two Diastereoisomers of the Potent HIV-1 Protease Inhibitor Saquinavir (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bmc.2007.10.020 (literal)
Alternative label
  • Righi G., Ciambrone S., Bonini C., Campaner P. (2007)
    Stereocontrolled Synthesis and Biological Activity of two Diastereoisomers of the Potent HIV-1 Protease Inhibitor Saquinavir
    in Bioorganic & medicinal chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Righi G., Ciambrone S., Bonini C., Campaner P. (literal)
Pagina inizio
  • 902 (literal)
Pagina fine
  • 908 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 16 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR, ICB-UOS Roma (literal)
Titolo
  • Stereocontrolled Synthesis and Biological Activity of two Diastereoisomers of the Potent HIV-1 Protease Inhibitor Saquinavir (literal)
Abstract
  • A general enantioselective synthesis of new syn-hydroxyethylamine isosteres has been developed. The approach, based on the controlled opening of functionalized optically active 2,3-epoxy amines, can be conveniently used for the preparation of new peptidomimetics with various residues. Finally the total synthesis of two diastereoisomer analogues of HIV-Protease inhibitor Saquinavir has been achieved and their biological activity evaluated. (C) 2007 Elsevier Ltd. All rights reserved. (literal)
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