3-O-methylfunicone produced by Penicillium pinophilum affects cell motilità of breast cancer cells, downregulating avb5 integrin and inhibiting metalloproteinase-9 secretion. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• 3-O-methylfunicone produced by Penicillium pinophilum affects cell motilità of breast cancer cells, downregulating avb5 integrin and inhibiting metalloproteinase-9 secretion. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/mc.20322 (literal)

Alternative label

• E. Buommino, M. Boccellino, A. De Filippis, M. Petrazzuolo, V. Cozza, R. Nicoletti, M. L. Ciavatta, L. Quagliuolo, M. A. Tufano. (2007)
  3-O-methylfunicone produced by Penicillium pinophilum affects cell motilità of breast cancer cells, downregulating avb5 integrin and inhibiting metalloproteinase-9 secretion.
  in Molecular carcinogenesis (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• E. Buommino, M. Boccellino, A. De Filippis, M. Petrazzuolo, V. Cozza, R. Nicoletti, M. L. Ciavatta, L. Quagliuolo, M. A. Tufano. (literal)

Pagina inizio

• 930 (literal)

Pagina fine

• 940 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 46 (literal)

Rivista

• Molecular carcinogenesis (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, SUN, Naples, Italy Department of Biochemistry and Biophysics ''F. Cedrangolo'', Second University of Naples, Italy Department of Firm Strategies and Quantitative Methodologies, University of Naples Federico II, Italy C.R.A., Tobacco Experiment Institute, Scafati, Napoli, Italy Institute of Biomolecular Chemistry, C.N.R., Pozzuoli, Napoli, Italy (literal)

Titolo

• 3-O-methylfunicone produced by Penicillium pinophilum affects cell motilità of breast cancer cells, downregulating avb5 integrin and inhibiting metalloproteinase-9 secretion. (literal)

Abstract

• Recent evidence assigns integrins and metalloproteinases (MMPs) an important role in regulating tumor cell progression. Here, we demonstrate that 3-O-methylfunicone (OMF), a secondary metabolite produced by Penicillium pinophilum, affects cell proliferation and motility of breast cancer MCF-7 cells, downregulating avb5 integrin, and inhibiting MMP-9 secretion. This effect was absent when the non-tumoral MCF-10 cell line was used. Inhibition of cell motility was also associated to modifications in cell shape and in the distribution of tubulin fibers of OMF-treated MCF- 7 cells. In addition, a possible effect on survivin and hTERT was also investigated. We found that OMF strongly inhibits survivin and hTERT gene expression. The results of this study indicate that OMF-induced inhibition of cell motility may be mediated through the modulation of avb5 integrin and MMP-9 secretion. In addition, the inhibition of typical markers of tumor progression such as hTERT and survivin in MCF-7 and their inactivity towards MCF10 provide strong evidence for a potential use of OMF in anticancer therapy. (literal)

Prodotto di

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Esplorazione della diversità chimica in organismi marini in funzione del drug discovery (PM.P01.020.001) (Modulo)

Autore CNR

• MARIA LETIZIA CIAVATTA (Unità di personale interno)

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Incoming links:

Autore CNR di

• MARIA LETIZIA CIAVATTA (Unità di personale interno)

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Esplorazione della diversità chimica in organismi marini in funzione del drug discovery (PM.P01.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular carcinogenesis (Rivista)

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• Parole chiave di "3-O-methylfunicone produced by Penicillium pinophilum affects cell motilità of breast cancer cells, downregulating avb5 integrin and inhibiting metalloproteinase-9 secretion." (Insieme di parole chiave)