http://www.cnr.it/ontology/cnr/individuo/prodotto/ID15526
A Polysaccharide from Tomato (Lycopersicon esculentum) Peels Affects NF-kB Activation in LPS-Stimulated J774 Macrophages. (Articolo in rivista)
- Type
- Label
- A Polysaccharide from Tomato (Lycopersicon esculentum) Peels Affects NF-kB Activation in LPS-Stimulated J774 Macrophages. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1021/np070168z (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- De Stefano D.; Tommonaro G.; Simeon V.; Poli A.; Nicolaus B.; Carnuccio R. (literal)
- Pagina inizio
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- Scopu (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Farmacologia Sperimentale, Facoltà di Scienze Biotecnologiche, UniVersità degli Studi di Napoli \"Federico II\", Via D.Montesano, 49, 80131 Napoli, Italy
Istituto di Chimica Biomolecolare (ICB)-CNR, Via Campi Flegrei, 34-80078 Pozzuoli (NA), Italy (literal)
- Titolo
- A Polysaccharide from Tomato (Lycopersicon esculentum) Peels Affects NF-kB Activation in LPS-Stimulated J774 Macrophages. (literal)
- Abstract
- We investigated the effect of PS (1) on nitrite and reactive oxygen species (ROS) production in J774 macrophages stimulated with bacterial lipopolysaccharide (LPS) for 24 h. PS (1) inhibited in a concentration-dependent manner nitrite and ROS production as well as inducible nitric oxide synthase (iNOS) protein expression induced by LPS. Incubation of cells with PS (1) determined a significant decrease of nuclear factor-?B (NF-?B)/DNA binding activity which was correlated with a marked reduction of iNOS mRNA levels. These results show that PS (1) inhibits NF-?B activation and iNOS gene expression by preventing the reactive species production and suggest a role for this compound in controlling oxidative stress and/or inflammation. (literal)
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