Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/sj.ijo.0803539 (literal)

Alternative label

• Côté M; Matias I; Lemieux I; Petrosino S; Alméras N; Després JP; Di Marzo V (2007)
  Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men
  in International journal of obesity
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Côté M; Matias I; Lemieux I; Petrosino S; Alméras N; Després JP; Di Marzo V (literal)

Pagina inizio

• 692 (literal)

Pagina fine

• 699 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.nature.com/ijo/journal/v31/n4/pdf/0803539a.pdf (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 31 (literal)

Rivista

• International journal of obesity (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Hôpital Laval Research Centre, Québec, Canada Department of Anatomy and Physiology, Laval University, Québec, Canada Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada (literal)

Titolo

• Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men (literal)

Abstract

• The link between excess intra-abdominal adiposity (IAA) and metabolic complications leading to type 2 diabetes and cardiovascular disease is well recognized. Blockade of endocannabinoid action at cannabinoid CB(1) receptors was shown to reduce these complications. Here, we investigated the relationship between IAA, circulating endocannabinoid levels and markers of cardiometabolic risk in male obese subjects. DESIGN, SUBJECTS AND MEASUREMENTS: Fasting plasma levels of the endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), were measured by liquid chromatography-mass spectrometry in a study sample of 62 untreated asymptomatic men with body mass index (BMI) from 18.7 to 35.2 kg/m(2). Plasma 2-AG, but not AEA, levels correlated positively with BMI, waist girth, IAA measured by computed tomography, and fasting plasma triglyceride and insulin levels, and negatively with high-density lipoprotein cholesterol and adiponectin levels. Obese men with similar BMI values (> or =30 kg/m(2)) but who markedly differed in their amount of IAA (< vs > or = 130 cm(2), n=17) exhibited higher 2-AG levels in the presence of high IAA. No difference in 2-AG concentrations was observed between obese men with low levels of IAA vs nonobese controls. These results provide evidence for a relationship in men between a key endocannabinoid, 2-AG, and cardiometabolic risk factors, including IAA. (literal)

Prodotto di

• Struttura, funzione e \"profiling\" di endocannabinoidi e ammidi bioattive di acidi grassi implicati nelle patologie umane (PM.P01.012.001) (Modulo)
• Istituto di chimica biomolecolare (ICB) (Istituto)

Autore CNR

• VINCENZO DI MARZO (Unità di personale interno)
• STEFANIA PETROSINO (Unità di personale esterno)
• SANDRA ISABELLE MATIAS (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Struttura, funzione e \"profiling\" di endocannabinoidi e ammidi bioattive di acidi grassi implicati nelle patologie umane (PM.P01.012.001) (Modulo)

Autore CNR di

• VINCENZO DI MARZO (Unità di personale interno)
• STEFANIA PETROSINO (Unità di personale esterno)
• SANDRA ISABELLE MATIAS (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International journal of obesity (Rivista)

Insieme di parole chiave di

• Keywords of "Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men" (Insieme di parole chiave)