Ceratamines, Structurally Simple Microtubule-Stabilizing Antimitotic Agents with Unusual Cellular Effects (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Ceratamines, Structurally Simple Microtubule-Stabilizing Antimitotic Agents with Unusual Cellular Effects (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1158/0008-5472.CAN-04-4369 (literal)

Alternative label

• Karjala G.; Chan Q.; Manzo E.; Andersen R.J.;Roberge M. (2005)
  Ceratamines, Structurally Simple Microtubule-Stabilizing Antimitotic Agents with Unusual Cellular Effects
  in Cancer research (Chic. Ill.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Karjala G.; Chan Q.; Manzo E.; Andersen R.J.;Roberge M. (literal)

Pagina inizio

• 3040 (literal)

Pagina fine

• 3043 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://cancerres.aacrjournals.org/content/65/8/3040.abstract (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 65 (literal)

Rivista

• Cancer research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Departments of 1Biochemistry and Molecular Biology and 2Chemistry and Oceanography (EOS), University of British Columbia, Vancouver, British Columbia, Canada Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, I 80078 Pozzuoli, Naples, Italy. (literal)

Titolo

• Ceratamines, Structurally Simple Microtubule-Stabilizing Antimitotic Agents with Unusual Cellular Effects (literal)

Abstract

• Ceratamine A and ceratamine B are heterocyclic alkaloids recently identified in a screen for compounds that arrest cells in mitosis. Treatment of breast carcinoma MCF-7 cells causes a concentration-dependent block of cell cycle progression exclusively at mitosis. In vitro studies with purified tubulin indicate that the ceratamines directly stimulate microtubule polymerization in the absence of microtubule-associated proteins. Cells treated with ceratamines show a dense perinuclear microtubule network in interphase and multiple pillar-like tubulin structures in mitotic cells. The ceratamines do not compete with paclitaxel for binding to microtubules in vitro. Unlike other microtubule-stabilizing agents, the ceratamines have simple structures with no chiral centers, making them attractive drug leads. (Cancer Res 2005; 65(8): 3040-3) (literal)

Prodotto di

• Esplorazione della diversità chimica in organismi marini in funzione del drug discovery (PM.P01.020.001) (Modulo)
• Institute of biomolecular chemistry (ICB) (Istituto)

Autore CNR

• EMILIANO MANZO (Unità di personale interno)

Incoming links:

Autore CNR di

• EMILIANO MANZO (Unità di personale interno)

Prodotto

• Institute of biomolecular chemistry (ICB) (Istituto)
• Esplorazione della diversità chimica in organismi marini in funzione del drug discovery (PM.P01.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer research (Rivista)