Synthesis and Evaluation of Neuroprotective alpha,beta-Unsaturated Aldehyde Scavenger Histidyl-Containing Analogues of Carnosine (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synthesis and Evaluation of Neuroprotective alpha,beta-Unsaturated Aldehyde Scavenger Histidyl-Containing Analogues of Carnosine (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/jm050507q (literal)

Alternative label

• Andrea Guiotto; Andrea Calderan; Paolo Ruzza; Alessio Osler; Chiara Rubini; Dong-Gyu Jo; Mark. P. Mattson; Gianfranco Borin (2005)
  Synthesis and Evaluation of Neuroprotective alpha,beta-Unsaturated Aldehyde Scavenger Histidyl-Containing Analogues of Carnosine
  in Journal of medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Andrea Guiotto; Andrea Calderan; Paolo Ruzza; Alessio Osler; Chiara Rubini; Dong-Gyu Jo; Mark. P. Mattson; Gianfranco Borin (literal)

Pagina inizio

• 6156 (literal)

Pagina fine

• 6161 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 48 (literal)

Rivista

• Journal of medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 19 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Biomolecular Chemistry of CNR, Padova Unit, via F. Marzolo, 1, 35131 Padova, Italy; Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224-6825 (literal)

Titolo

• Synthesis and Evaluation of Neuroprotective alpha,beta-Unsaturated Aldehyde Scavenger Histidyl-Containing Analogues of Carnosine (literal)

Abstract

• The synthesis, scavenging activity, and cytoprotective profiles of histidyl-containing carnosine analogues bearing hydrazide or 1,2-diol moieties is reported. Some compounds have demonstrated higher aldehyde-sequestering efficiency than carnosine and were also efficient in protecting SH-SY5Y neuroblastoma cells and rat hippocampal neurons from 4-hydroxy-trans- 2,3-nonenal (HNE)-mediated death. The cytoprotective efficacy of these compounds suggests their potential use as therapeutic agents for disorders that involve excessive membrane lipids peroxidation and HNE-mediated neuronal toxicity. (literal)

Prodotto di

• Istituto di chimica biomolecolare (ICB) (Istituto)

Autore CNR

• ANDREA GUIOTTO (Unità di personale interno)
• ANDREA CALDERAN (Unità di personale interno)
• PAOLO RUZZA (Persona)
• GIANFRANCO BORIN (Persona)

Incoming links:

Autore CNR di

• ANDREA GUIOTTO (Unità di personale interno)
• PAOLO RUZZA (Persona)
• ANDREA CALDERAN (Unità di personale interno)
• GIANFRANCO BORIN (Persona)

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of medicinal chemistry (Rivista)