Impact of 1,5-disubstituted tetrazole ring on chelating ability of d-selective opioid peptide. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Impact of 1,5-disubstituted tetrazole ring on chelating ability of d-selective opioid peptide. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jinorgbio.2003.11.011 (literal)

Alternative label

• Lodyga-Chruscinska E., Oldziej S., Micera G., Sanna D., Chruscinski L., Olczak J., Zabrocki J. (2004)
  Impact of 1,5-disubstituted tetrazole ring on chelating ability of d-selective opioid peptide.
  in Journal of inorganic biochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lodyga-Chruscinska E., Oldziej S., Micera G., Sanna D., Chruscinski L., Olczak J., Zabrocki J. (literal)

Pagina inizio

• 447 (literal)

Pagina fine

• 458 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0162013403004549 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 98 (literal)

Rivista

• Journal of inorganic biochemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of General Food Chemistry, Technical University of ?ód?, ul. Stefanowskiego 4/10, Lód? 90-924, Poland Faculty of Chemistry, University of Gda?sk, Sobieskiego 18, Gda?sk 80-952, Poland Department of Chemistry, University of Sassari, Via Vienna 2, Sassari 07100, Italy Istituto C.N.R. Chim. Biomolecolare, Trav. La Crucca 3, reg. Baldinca, Sassari 07040, Italy Faculty of Process and Environmental Engineering, Technical University of ?ód?, ul. Wólcza?ska 213, ?ód? 90-924, Poland Institute of Organic Chemistry, Technical University of ?ód?, ul. ?eromskiego 176, ?ód? 90-924, Poland (literal)

Titolo

• Impact of 1,5-disubstituted tetrazole ring on chelating ability of d-selective opioid peptide. (literal)

Abstract

• Complex formation between Cu(II) and three tetrazole analogues of opioid peptide - deltorphin I has been investigated. In potentiometric and spectroscopic (UV-Vis, CD and EPR) studies have been established the thermodynamic stability, speciation and structure of Cu(II) complexes with Tyr-d-Ala-Phe-Asp-Val-Val-Gly-NH2 (L1), Tyr-?(CN4)-Gly-Phe-Asp-Val-Val-Gly-NH2 (L2), Tyr-Gly-?(CN4)-Phe-Asp-Val-Val-Gly-NH2 (L3) and Tyr-d-Ala-?(CN4)-Phe-Asp-Val-Val-Gly-NH2 (L4). The site of the insertion of tetrazole moiety ?(CN4) into the peptide sequences has critical impact on their co-ordination ability. Comparison of the binding ability of the tetrazole analogues reveals that around physiological pH region the L3 and L4 are more effective ligands for copper(II) than L1 and L2. The peptide conformation changes achieved by Cu(II) co-ordination may be essential for binding of the tetrazole deltorphins at the opiate receptors. (literal)

Prodotto di

• Institute of biomolecular chemistry (ICB) (Istituto)
• Caratterizzazione di complessi metallici formati da proteine coinvolte in patologie correlate al disordine conformazionale proteico. (PM.P01.004.002) (Modulo)

Autore CNR

• DANIELE SANNA (Unità di personale interno)

Incoming links:

Autore CNR di

• DANIELE SANNA (Unità di personale interno)

Prodotto

• Institute of biomolecular chemistry (ICB) (Istituto)
• Caratterizzazione di complessi metallici formati da proteine coinvolte in patologie correlate al disordine conformazionale proteico. (PM.P01.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of inorganic biochemistry (Rivista)