The endogenous cannabinoid system controls extinction of aversive memories (Articolo in rivista)

Type
Label
  • The endogenous cannabinoid system controls extinction of aversive memories (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Marsicano G., Wotjak C.T., Rammes G., Bisogno T., Azad S.C., Cascio M.G., Hermann H., Tang J., Hofmann C., Zieglgdnsberger W., Di Marzo V., Lutz B. (2002)
    The endogenous cannabinoid system controls extinction of aversive memories
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Marsicano G., Wotjak C.T., Rammes G., Bisogno T., Azad S.C., Cascio M.G., Hermann H., Tang J., Hofmann C., Zieglgdnsberger W., Di Marzo V., Lutz B. (literal)
Pagina inizio
  • 530 (literal)
Pagina fine
  • 534 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 418 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Prima evidenza mai pubblicata riguardante il coinvolgimento del sistema endocannabinoide nei processi molecolari che regolano la memoria ed in particolare l’estinzione della memoria avversa. Mediante l’utilizzo di topi deprivati del gene che codifica per il recettore CB1 dei cannabinoidi si è evidenziato il diretto coinvolgimento dei cannabinoidi nella fase di estinzione della memoria avversa ma non in quella di acquisizione o consolidamento. Tale tipo di studio risulta essere di primaria importanza per lo sviluppo di terapie alternative per la cura di disordini legati ad eventi post-traumatici o fobie. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Molecular Genetics of Behaviour, Neuronal Plasticity/Mouse Behaviour and Neuropharmacology Group, Max Planck Institute of Psychiatry, Munich, Germany; Clinic of Anaesthesiology, Klinikum Grosshadem, Ludwig-Maximilians-University, Munich, Germany; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, Via Campi Flegrei 34, 80078 Pozzuoli (Napoli), Italy, and Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, -Munich, Germany (literal)
Titolo
  • The endogenous cannabinoid system controls extinction of aversive memories (literal)
Abstract
  • Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct. Despite the importance of extinction, its cellular mechanisms are largely unknown. The cannabinoid receptor 1 (CB1) and endocannabinoids are present in memory-related brain areas and modulate memory. Here we show that the endogenous cannabinoid system has a central function in extinction of aversive memories. CB1- deficient mice showed strongly impaired short-term and long-term extinction in auditory fear-conditioning tests, with unaffected memory acquisition and consolidation. Treatment of wild-type mice with the CB1 antagonist SR141716A mimicked the phenotype of CB1-deficient mice, revealing that CB1 is required at the moment of memory extinction. Consistently, tone presentation during extinction trials resulted in elevated levels of endocannabinoids in the basolateral amygdala complex, a region known to control extinction of aversive memories. In the basolateral amygdala, endocannabinoids and CB1 were crucially involved in long-term depression of GABA (gamma-aminobutyric acid)-mediated inhibitory currents. We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Insieme di parole chiave di
data.CNR.it