One-pot synthesis of 6-hydroxyisochromans: the example of demethyl-oxa-coclaurine (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• One-pot synthesis of 6-hydroxyisochromans: the example of demethyl-oxa-coclaurine (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• M.GUISO, A.BIANCO, C.MARRA, C.CAVARISCHIA (2003)
  One-pot synthesis of 6-hydroxyisochromans: the example of demethyl-oxa-coclaurine
  in European journal of organic chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M.GUISO, A.BIANCO, C.MARRA, C.CAVARISCHIA (literal)

Pagina inizio

• 3407 (literal)

Pagina fine

• 3411 (literal)

Rivista

• European journal of organic chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• One-pot synthesis of 6-hydroxyisochromans: the example of demethyl-oxa-coclaurine (literal)

Abstract

• Using a modified oxa-Pictet Spengler reaction that we recently described, we synthesized 6-hydroxy-isochromans and their 7-hydroxy derivatives. The synthesis, which consists of one step and does not require protecting groups, was successful and provided high yields. The obtainment of 1-(4'-hydroxy-benzyl)-6,7-dihydroxy-isochroman (1) indicates that this protocol can be used to synthesize oxygenated analogues of benzyl-tetrahydroisoquinoline alkaloids, such as demethyl-coclaurine (2). This methodology could be applied as a general procedure for the synthesis of hydroxy-isochromans. (literal)

Prodotto di

• Institute of biomolecular chemistry (ICB) (Istituto)

Incoming links:

Prodotto

• Institute of biomolecular chemistry (ICB) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of organic chemistry (Rivista)