Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Furin A., Guiotto A., Baccichetti F., Pasut G., Deuschel C., Bertani R., Veronese F.M. (2003)
  Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates
  in European journal of medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Furin A., Guiotto A., Baccichetti F., Pasut G., Deuschel C., Bertani R., Veronese F.M. (literal)

Pagina inizio

• 739 (literal)

Pagina fine

• 749 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 38 (literal)

Rivista

• European journal of medicinal chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates (literal)

Abstract

• Oxalate 1,2 – diaminocyclohexane platinum (oxaliplatin), a successfully employed platinum compound belonging to the family of Pt-DACH complexes, has been conjugated to different molecular weight poly(ethylene glycols) (PEG) by means of peptide spacers and a malonic acid bidentate residue. Tri- and tetrapeptidic substrates of lysosomal enzymes were used in order to increase the release of Pt-DACH complex inside the cell following endocytosis and enzymatic degradation of the peptide spacer. Other aminoacids (e.g. norleucine) have been also employed. 1H NMR of some conjugates was performed as characterisation of the product, while 195Pt-NMR analysis was carried out to detect the rearrangement of the platinum complex from the Pt(O,O) to the Pt(O,N) form. The compound PEG(5000)-Nle-malonato-Pt-DACH has been tested against L1210-implanted mice and showed an appreciable increase in cytotoxicity as compared to the reference standard dichloroPtDACH. (literal)

Prodotto di

• Institute of biomolecular chemistry (ICB) (Istituto)

Autore CNR

• ANDREA GUIOTTO (Unità di personale interno)

Incoming links:

Autore CNR di

• ANDREA GUIOTTO (Unità di personale interno)

Prodotto

• Institute of biomolecular chemistry (ICB) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of medicinal chemistry (Rivista)