PEGylation of the antimicrobial peptide nisin A: problems and perspectives (Articolo in rivista)

Type
Label
  • PEGylation of the antimicrobial peptide nisin A: problems and perspectives (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Guiotto A., Pozzobon M., Canevari M., Manganelli R., Scarin M., Veronese F.M. (2003)
    PEGylation of the antimicrobial peptide nisin A: problems and perspectives
    in Il Farmaco (Pavia)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Guiotto A., Pozzobon M., Canevari M., Manganelli R., Scarin M., Veronese F.M. (literal)
Pagina inizio
  • 45 (literal)
Pagina fine
  • 50 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 58 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • PEGylation of the antimicrobial peptide nisin A: problems and perspectives (literal)
Abstract
  • Nisin is a natural antimicrobial peptide produced by Lactococcus lactis and widely employed as food preservative. Its low solubility in neutral aqueous solutions, its instability at physiological pH and its rapid breakdown by proteolytic enzymes has limited its use for processed foods (processed cheese, milk and derivatives, canned vegetables). The conjugation to poly(ethylene glycol) (PEG) could improve its solubility and protect it towards enzymes present in non optimally processed food. We report the synthesis of a PEG-nisin conjugate, and the microbiology assays against some bacterial cell lines. (literal)
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