Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors (Articolo in rivista)

Type
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  • Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/S0014-5793(01)02934-9 (literal)
Alternative label
  • De Petrocellis L., Davis J.B. and Di Marzo V. (2001)
    Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors
    in FEBS letters (Print); ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Petrocellis L., Davis J.B. and Di Marzo V. (literal)
Pagina inizio
  • 253 (literal)
Pagina fine
  • 256 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 506 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. CNR, Ist Chim Mol Interesse Biol, I-80078 Pozzuoli, Naples, Italy 2. CNR, Ist Cibernetica, Endocannabinoid Res Grp, I-80078 Pozzuoli, Naples, Italy 3. GlaxoSmithKline, Neurol CEDD, Harlow CM19 5AW, Essex, England (literal)
Titolo
  • Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors (literal)
Abstract
  • In human embryonic kidney cells over-expressing the human vanilloid receptor type 1 (VR1), palmitoylethanolamide (PEA, 0.5-10 microM) enhanced the effect of arachidonoylethanolamide (AEA, 50 nM) on the VR1-mediated increase of the intracellular Ca2+ concentration. PEA (5 microM) decreased the AEA half-maximal concentration for this effect from 0.44 to 0.22 microM. The PEA effect was not due to inhibition of AEA hydrolysis or adhesion to non-specific sites, since bovine serum albumin (0.01-0.25%) potently inhibited AEA activity, and PEA also enhanced the effect of low concentrations of the VR1 agonists resiniferatoxin and capsaicin. PEA (5 microM) enhanced the affinity of AEA for VR1 receptors as assessed in specific binding assays. These data suggest that PEA might be an endogenous enhancer of VR1-mediated AEA actions. (literal)
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