http://www.cnr.it/ontology/cnr/individuo/prodotto/ID142987

The interleukin-1 receptor family. (Contributo in volume (capitolo o saggio))

Type

Contributo in volume (capitolo o saggio) (Classe)
Prodotto della ricerca (Classe)

Label

The interleukin-1 receptor family. (Contributo in volume (capitolo o saggio)) (literal)

Anno

2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.smim.2013.10.023 (literal)

Alternative label

Boraschi D, Tagliabue A (2013)
The interleukin-1 receptor family.
Elsevier Ltd, Oxford (Regno Unito) in seminars in immunology, 2013
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Boraschi D, Tagliabue A (literal)

Pagina inizio

394 (literal)

Pagina fine

407 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#citta

San Diego/Amsterdam (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume

seminars in immunology (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana

25 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

13 (literal)

Note

Science direct - Elsevier (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Diana Boraschi: Institute of Biomedical Technologies National Research Council, Pisa, Italy Aldo Tagliabue: ALTA S.r.l., Siena, Italy (literal)

Titolo

The interleukin-1 receptor family. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#inCollana

Interleukins. Vitamins and Hormones (literal)

Abstract

The activity of each member of the IL-1 family of ligands is mediated by its own receptor. Each ligand binds specifically to the extracellular \"ligand binding chain\" containing three Ig-like regions. With the exception of the IL-1 and IL-36 receptor antagonists, a second chain, termed the \"accessory chain\", is recruited, forms a heterotrimetic complex with the ligand binding chain and the ligand, and signal transduction is initiated. Each ligand binding or accessory chain shares a common cytosolic segment termed the Toll-IL-1-receptor (TIR) domain. Another family of 13 receptors, termed Toll-like receptors (TLR), have extracellular leucine-rich repeat domains, which bind a broad spectrum of microbial products. All TLR share a nearly identical TIR domain with all members of the IL-1 receptor family. Hence signal transduction and the biological consequences of TLR ligands and IL-1 family ligands are often the same and both receptor families contribute to innate inflammation and host defense. The IL-1 family of receptors is comprised of ten distinct but related gene products. The receptors are indicated by the term IL-1 receptor (IL-1R) followed by a numeral, assigned chronologically by discovery, for example, IL-1R1, IL-1R2, IL-1R3, etc. The ligand binding chain for IL-1? and IL-1? is IL-1R1 and the accessory chain is IL-1R3. IL-1?, IL-1?, IL-33 and IL-36 use IL-1R3 as their accessory chain. IL-1R2 is a non-signalling \"decoy\" receptor that sequesters the IL-1? and IL-1R3. IL-1R8 exhibits anti-inflammatory properties by reducing IL-1 and TLR signalling. Presently there are two orphan receptors, IL-1R9 and IL-1R10, which have no known function. This review examines the characteristics and functional roles of the IL-1R family in the regulation of innate inflammation, host defense and acquired immunity. (literal)

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