Nickel(II) and mixed metal complexes of amyloid-b N-terminus. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Nickel(II) and mixed metal complexes of amyloid-b N-terminus. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c0dt00189a (literal)

Alternative label

• Eva Jozsa1; Katalin Osz2; Csilla Kallay1; Paolo de Bona3; Chiara A. Damante3; Giuseppe Pappalardo4; Enrico Rizzarelli3; Imre Sovago1 (2010)
  Nickel(II) and mixed metal complexes of amyloid-b N-terminus.
  in Dalton transactions (2003. Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Eva Jozsa1; Katalin Osz2; Csilla Kallay1; Paolo de Bona3; Chiara A. Damante3; Giuseppe Pappalardo4; Enrico Rizzarelli3; Imre Sovago1 (literal)

Pagina inizio

• 7046 (literal)

Pagina fine

• 7053 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 39 (literal)

Rivista

• Dalton transactions (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 University of Debrecen, Department of Inorganic and Analytical Chemistry, H-4010, Debrecen, Hungary 2 University of Debrecen, Department of Physical Chemistry, H-4010, Debrecen, Hungary 3 University of Catania, Department of Chemical Sciences, 95125, Catania, Italy 4 CNR, Institute of Biostructures and Bioimaging, Catania, 95125, Catania, Italy (literal)

Titolo

• Nickel(II) and mixed metal complexes of amyloid-b N-terminus. (literal)

Abstract

• Nickel(II) complexes of Ab(1-16)Y10A and its smaller fragments including Ab(1-4), Ab(1-6), Ac-Ab(1-6) and Ac-Ab(8-16)Y10A have been studied by potentiometric, UV-Vis and circular dichroism spectroscopic measurements. The formation of mixed metal complexes and the distribution of metal ions among the possible coordination sites in the Cu(II)-Ni(II)-Ab(1-16)Y10A and Cu(II)-Ni(II)-Zn(II)-Ab(1-16)Y10A systems have also been evaluated. It was found that the hexadecapeptide and its fragments are effective nickel(II) binding ligands and complex formation processes of nickel(II) ions are quite similar to those of copper(II). Formation of mono- and di-nuclear complexes was detected in the nickel(II)-Ab(1-16)Y10A system suggesting the existence of two separated metal binding motifs: the N-terminus and internal histidyl residues. The preference for the coordination at the N-terminus was supported by the spectroscopic measurements but in equilibrium with the metal binding at the internal histidyl sites. Neither zinc(II) nor nickel(II) can, however, substitute copper(II) in the mixed metal complexes of Ab(1-16)Y10A, but both metal ions are able to alter the distribution of copper(II) ions among the various binding sites. Both N-terminus (amino and His6) and internal histidyl residues (His13 and His14) can work as dinuclear binding motifs, preferably accommodating copper(II) and zinc(II), respectively, while nickel(II) can occupy the remaining free coordination sites. (literal)

Prodotto di

• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• ENRICO RIZZARELLI (Unità di personale esterno)

Incoming links:

Autore CNR di

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• ENRICO RIZZARELLI (Unità di personale esterno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Dalton transactions (Rivista)