Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/b719930a (literal)

Alternative label

• Raffaele Pietro Bonomo ; Giuseppe Pappalardo; Enrico Rizzarelli; Giovanni Tabbì; Laura Irene Vagliasindi (2008)
  Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments
  in Dalton transactions (2003. Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Raffaele Pietro Bonomo ; Giuseppe Pappalardo; Enrico Rizzarelli; Giovanni Tabbì; Laura Irene Vagliasindi (literal)

Pagina inizio

• 3805 (literal)

Pagina fine

• 3816 (literal)

Rivista

• Dalton transactions (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Bonomo R.P., L.I. Vagliasindi: Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy (literal)

Titolo

• Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (literal)

Abstract

• The interaction of nitric oxide with copper(II) complexes of two octarepeat sequences belonging to the prion protein was studied, considering both mononuclear and dinuclear systems, i.e. Cu-Ac-(PHGGGWGQ)2-NH2 and Cu2-Ac-(PHGGGWGQ)2-NH2, respectively. The NO interaction with both systems was followed in aqueous solutions at physiological pH value, by using UV-Vis and EPR spectroscopic techniques as well as cyclic voltammetry. The mechanism of NO interaction with the mononuclear copper complex can be considered similar to that previously observed for the analogous copper systems with Ac-HGGG-NH2 and Ac-PHGGGWGQ-NH2. A more complicated behaviour was found with the copper dinuclear system, in which the involvement of two different intermediate complex species was evidenced. A positive cooperativity between the two copper ions, in the reduction process was inferred. When working with a large excess of the Ac-(PHGGGWGQ)2-NH2 ligand, the frozen-solution EPR parameters pertain to the well characterized [Cu(Nim)4]2+ unit, which did not exhibit any interaction with NO. The presence of a free coordination site is the necessary requirement for the NO interaction to occur, as found only in the square-pyramidal geometry of [Cu(L)H-2] or [Cu2(L)H-4] complex species, which form when copper and ligand concentrations are similar. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Autore CNR

• ENRICO RIZZARELLI (Unità di personale esterno)
• GIOVANNI TABBI' (Persona)
• GIUSEPPE PAPPALARDO (Unità di personale interno)

Incoming links:

Autore CNR di

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• GIOVANNI TABBI' (Persona)
• ENRICO RIZZARELLI (Unità di personale esterno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Dalton transactions (Rivista)