Comparison of Myocardial Perfusion Rb-82 PET Performed with CT- and Transmission CT-Based Attenuation Correction (Articolo in rivista)

Type
Label
  • Comparison of Myocardial Perfusion Rb-82 PET Performed with CT- and Transmission CT-Based Attenuation Correction (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Slomka PJ; Le Meunier L; Hayes SW; Acampa W; Oba M; Haemer GG; Berman DS; Germano G; (2008)
    Comparison of Myocardial Perfusion Rb-82 PET Performed with CT- and Transmission CT-Based Attenuation Correction
    in The Journal of nuclear medicine (1978. Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Slomka PJ; Le Meunier L; Hayes SW; Acampa W; Oba M; Haemer GG; Berman DS; Germano G; (literal)
Pagina inizio
  • 1992 (literal)
Pagina fine
  • 1998 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 49 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA. (literal)
Titolo
  • Comparison of Myocardial Perfusion Rb-82 PET Performed with CT- and Transmission CT-Based Attenuation Correction (literal)
Abstract
  • CT-based attenuation correction (AC) for myocardial perfusion PET studies is challenging because of respiratory motion. Our study aimed to compare the transmission CT (TCT)-based and CT-based AC for myocardial perfusion PET/CT images with a direct semiquantitative approach comparing differences in segmental count distribution. METHODS: Stress and rest (82)Rb PET scans from 54 consecutive patients acquired on a PET/CT scanner with dual CT-based and TCT-based AC were considered. TCT- and CT-based AC images were automatically registered to each other, and direct voxel-based and American Heart Association segment-based estimation of positive and negative changes between these scans was performed. Additionally, visual quality control (QC) of CT map alignment with PET emission data was performed by 2 expert observers, and studies with significant (>/=5 mm) misalignment were reprocessed with corrected CT alignment. RESULTS: We used the 17-segment American Heart Association model for TCT-to-CT regional change analysis in all patients and found that 4 segments on rest and 4 segments on stress scans differed more than 3% between CT- and TCT-corrected images for studies without significant misalignments (<5 mm); only 1 differed by more than 5%. In cases with significant misalignment of greater than or equal to 3% TCT-CT AC, changes were observed on 14 rest and 10 stress segments; after alignment, these differences were still seen in 13 rest segments and 11 stress segments. Visual QC revealed that 46% of rest and 54% of stress PET scans were misaligned by greater than or equal to 5 mm with the CT maps acquired during normal breathing. The range of the reported PET/CT misalignment was 0-15 mm in x, 0-16 mm in y, and 0-20 mm in z directions. The overall agreement in visual QC of PET/CT alignment between the observers was 72.2% CONCLUSION: There are significant differences between TCT and CT AC applied to cardiac PET/CT studies, which remain after alignment of CT maps to emission data. (literal)
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