http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13684
Characteristics, associations and outcome of partial agenesis of the corpus callosum in the fetus. (Articolo in rivista)
- Type
- Label
- Characteristics, associations and outcome of partial agenesis of the corpus callosum in the fetus. (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Volpe P; Paladini D; Resta M; Stanziano A; Salvatore M; Quarantelli M; De Robertis V; Buonadonna A; Caruso G; Gentile M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di biostrutture e bioimmagini (literal)
- Titolo
- Characteristics, associations and outcome of partial agenesis of the corpus callosum in the fetus. (literal)
- Abstract
- Objectives To report, in a population of fetuses diagnosed
with partial agenesis of the corpus callosum
(PACC), the sonographic characterization, incidence of
cerebral, extracerebral and chromosomal anomalies, and
outcome. In addition, in some of our cases a comparison
was made between findings on ultrasound and fetal
magnetic resonance imaging (MRI).
Methods This was a retrospective study of all cases of
PACC seen at two referral centers for prenatal diagnosis
of congenital anomalies over a 10-year period.
The following variables were assessed: indication for
referral, additional cerebral and extracerebral malformations,
chromosomal abnormalities, and pregnancy and
fetal/neonatal outcome.
Results Among 54 cases of fetal agenesis of the corpus
callosum detected in the referral centers during the
observation period, PACC was diagnosed at prenatal
sonography in 20 cases and confirmed at pre/postnatal
MRI and necropsy examinations in 19 cases (35%).
These 19 constituted the study group. The diagnosis
was made in the sagittal planes and in 12 cases it was
made prior to 24 weeks. In most cases the indication for
referral was the presence of indirect signs of callosal
anomalies, such as colpocephaly. In 10 cases PACC
occurred in association with other anomalies and in
nine it was isolated. MRI was particularly useful for
demonstrating some additional cerebral anomalies such
as late sulcation, migrational pathological conditions
and heterotopia. Regarding pregnancy outcome, of
those diagnosed before 24 weeks which had associated
anomalies, all except two were terminated. Of the nine
cases with isolated PACC, all were liveborn. Follow-up
was available in eight, and two of these (25%) showed
evidence of significant developmental delay. In our series
the outcome of isolated PACC was not better than that
of complete agenesis of the corpus callosum reported in
other series.
Conclusions PACC can be diagnosed reliably and
characterized in prenatal life. The sonographic sign
present in most cases is colpocephaly. Prenatal MRI can
be performed to confirm the diagnosis. It is particularly
useful to demonstrate some additional cerebral anomalies
such as late sulcation, migrational pathological conditions
and heterotopia. The relatively poor survival rate is due
to the high rate of terminations and associated major
anomalies. (literal)
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- Autore CNR
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