Protective Effect of Carnosine During Nitrosative Stress in Astroglial Cell Cultures. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Protective Effect of Carnosine During Nitrosative Stress in Astroglial Cell Cultures. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s11064-005-6874-8 (literal)

Alternative label

• Vittorio Calabrese; Claudia Colombrita; Eleonora Guagliano; Maria Sapienza M.; Agrippino Ravagna ; Venera Cardile; Giovanni Scapagnini; Anna Maria Santoro; Andrea Mangiameli; D.Allan Butterfield; Anna Maria Giuffrida Stella; Enrico Rizzarelli. (2005)
  Protective Effect of Carnosine During Nitrosative Stress in Astroglial Cell Cultures.
  in Neurochemical research; Springer Science+Business Media, Berlin, Heidelberg (Germania)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vittorio Calabrese; Claudia Colombrita; Eleonora Guagliano; Maria Sapienza M.; Agrippino Ravagna ; Venera Cardile; Giovanni Scapagnini; Anna Maria Santoro; Andrea Mangiameli; D.Allan Butterfield; Anna Maria Giuffrida Stella; Enrico Rizzarelli. (literal)

Pagina inizio

• 797 (literal)

Pagina fine

• 807 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 30 (literal)

Rivista

• Neurochemical research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• V. Calabrese, Department of Chemistry, Biochemistry Mol. Biology Section, Faculty of Medicine, University of Catania, Viale Andrea Doria 6 – 95100 Catania, Italy. Tel.: 39-095-738-4067; Fax: 39-095-580138; E-mail:calabres@mbox.unict.it Colombrita,Guagliano,Sapienza,Ravagna,A.M.Giuffrida Stella,E.Rizzarelli :ÿDepartment of Chemical Sciences, University of Catania, Italy. Cardile V.:Department of Physiological Sciences, University of Catania,Italy. A. Mangiameli:Department of Internal Medicine, University of Catania, Italy. D.A. Butterfield:Department of Chemistry, Center for Membrane Science, and Sander-Brown Center on Aging, University of Kentucky, Lex-ington, KY, USA. (literal)

Titolo

• Protective Effect of Carnosine During Nitrosative Stress in Astroglial Cell Cultures. (literal)

Abstract

• Formation of nitric oxide by astrocytes has been suggested to contribute, via impairment of mitochondrial function, to the neurodegenerative process. Mitochondria under oxidative stress are thought to play a key role in various neurodegenerative disorders; therefore protection by antioxidants against oxidative stress to mitochondria may prove to be beneficial in delaying the onset or progression of these diseases. Carnosine has been recently proposed to act as antioxidant in vivo. In the present study, we demonstrate its neuroprotective effect in astrocytes exposed to LPS- and INFc-induced nitrosative stress. Carnosine protected against nitric oxide-induced impairment of mitochondrial function. This effect was associated with decreased formation of oxidatively modified proteins and with decreased up-regulation oxidative stress-responsive genes, such as Hsp32, Hsp70 and mt-SOD. Our results sustain the possibility that carnosine might have anti-ageing effects to brain cells under pathophysiological conditions leading to degenerative damage, such as aging and neurodegenerative disorders. (literal)

Editore

• Springer Science+Business Media (Editore)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Autore CNR

• GIOVANNI SCAPAGNINI (Unità di personale interno)
• ANNA MARIA SANTORO (Unità di personale interno)

Incoming links:

Autore CNR di

• ANNA MARIA SANTORO (Unità di personale interno)
• GIOVANNI SCAPAGNINI (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurochemical research (Rivista)

Editore di

• Springer Science+Business Media (Editore)