Multiple Pathways in cancer development. (Monografia o trattato scientifico)

Type

• Monografia o trattato scientifico (Classe)
• Prodotto della ricerca (Classe)

Label

• Multiple Pathways in cancer development. (Monografia o trattato scientifico) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Mondello C (2008)
  Multiple Pathways in cancer development.
  Transworld Research Network, Kerala, 2008
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mondello C (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#citta

• Kerala (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Cancer is a complex disease, the main features of tumor cells are the loss of proliferation control and the acquisition of the ability to invade other tissues. There are more than 100 distinct types of cancer and deregulation of several different cellular pathways can lead to tumor development and progression. This book, which is far from being exhaustive, aims at covering some of the routes involved in cancer development. Chromosomal instability, a widespread characteristic of tumor cells, is discussed in chapter 1, together with the mechanisms leading to its development. Telomeres, the ends of eukaryotic chromosomes, are essential elements for chromosomal stability; their properties and their involvement in cancerogenesis are the topic of chapter 2. In chapter 3, gene amplification, a peculiar chromosomal anomaly of tumor cells, is reviewed. Key elements for the control of cell proliferation are cell cycle check points, their role in cancer is the subject of chapter 4. In recent years, RNA has become an important player in tumorigenesis. Two chapters of the book are dedicated to RNA and cancer. In chapter 5, alternative splicing, as a mean to produce aberrant tumorigenic isoforms, is illustrated. Chapter 6 reviews microRNAs and their role in controlling cancer-associated molecular pathways. For a cancer to develop, tumor cells have to be resistant to death and must be fed. Apoptosis and angiogenesis, involved in cell death and tumor feeding, respectively, are the topics of chapter 7 and 8. Deepening the knowledge on the molecular mechanisms leading to cancer, and on the interplay between different triggering factors, can give clues for the development of new therapeutic strategies and, hopefully, of targeted therapies. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Genetica Molecolare, CNR, Pavia, Italy (literal)

Titolo

• Multiple Pathways in cancer development. (literal)

Editore

• Transworld Research Network (Editore)

Prodotto di

• Malattie genetiche dovute a difetti nella riparazione del DNA che predispongono ai tumori. Analisi genetica funzionale dei fattori importanti per l'integrità del genoma. (ME.P05.005.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• CHIARA MONDELLO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Malattie genetiche dovute a difetti nella riparazione del DNA che predispongono ai tumori. Analisi genetica funzionale dei fattori importanti per l'integrità del genoma. (ME.P05.005.001) (Modulo)

Autore CNR di

• CHIARA MONDELLO (Unità di personale interno)

Editore di

• Transworld Research Network (Editore)