Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis. (Articolo in rivista)

Type
Label
  • Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1210/jc.2002-020373 (literal)
Alternative label
  • Spalletti-Cernia, Daniela; Sorrentino, Rosanna; Di Gaetano, Sonia; Arciello, Angela; Garbi, Corrado; Piccoli, Renata; D'Alessio, Giuseppe; Vecchio, Giancarlo; Laccetti, Paolo; Santoro, Massimo. (2003)
    Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis.
    in The Journal of clinical endocrinology and metabolism
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Spalletti-Cernia, Daniela; Sorrentino, Rosanna; Di Gaetano, Sonia; Arciello, Angela; Garbi, Corrado; Piccoli, Renata; D'Alessio, Giuseppe; Vecchio, Giancarlo; Laccetti, Paolo; Santoro, Massimo. (literal)
Pagina inizio
  • 2900 (literal)
Pagina fine
  • 2907 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 88 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (CNR), Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita` di Napoli Federico II (D.S.-C., R.S., C.G., G.V., M.S.), 80131 Naples, Italy; Dipartimento di Chimica Biologica, Universita` di Napoli Federico II (S.D.G., A.A., R.P., G.D., P.L.), 80134 Naples, Italy; and Istituto di Biostrutture e Bioimmagini-CNR (S.D.G.), 80134 Naples, Italy (literal)
Titolo
  • Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis. (literal)
Abstract
  • Bovine seminal RNase (BS-RNase), a natural dimeric homolog of bovine pancreatic RNase (RNase A), and HHP2-RNase, an engineered dimeric form of human pancreatic RNase (HP-RNase), are endowed with powerful antitumor effects. Here we show that BS- and HHP2-RNases, but not monomeric RNase A, induce apoptosis of human thyroid carcinoma cell lines. RNase-induced apoptosis was assocd. with activation of initiation caspase-8 and -9. This was followed by activation of executioner caspase-3, leading to the proteolytic cleavage of poly(ADP-ribose) polymerase. The caspase inhibitor Z-Val-Ala-Asp-(OMe)-fluoromethylketone protected thyroid cancer cells from BS-RNase-induced apoptosis. RNase-triggered apoptosis and caspase activation were accompanied by reduced phosphorylation of Akt/protein kinase B (PKB), a serine-threonine kinase that when phosphorylated is able to deliver survival signals to cancer cells. BS-RNase antitumor effects in nude mice were accompanied by caspase activation and apoptosis. Because of the high selectivity of apoptotic effects for malignant cells, BS- and HHP2-RNase are promising tools for the treatment of aggressive thyroid cancer. (literal)
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