Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Ab1-42 by mirror image phage display. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Ab1-42 by mirror image phage display. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Wiesehan, Katja; Buder, Katrin; Linke, Reinhold P.; Patt, Stephan; Stoldt, Matthias; Unger, Eberhard; Schmitt, Bettina; Bucci, Enrico; Willbold, Dieter. (2003)
  Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Ab1-42 by mirror image phage display.
  in ChemBioChem (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Wiesehan, Katja; Buder, Katrin; Linke, Reinhold P.; Patt, Stephan; Stoldt, Matthias; Unger, Eberhard; Schmitt, Bettina; Bucci, Enrico; Willbold, Dieter. (literal)

Pagina inizio

• 748 (literal)

Pagina fine

• 753 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 4 (literal)

Rivista

• ChemBioChem (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Articolo su rivista scientifica internazionale in cui vengono riportati screening di nuove molecole per troavre ligandi del beta amiloide, molecola coinvolta nel morbo di Alzheimer (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Forschungszentrum Jülich IBI-2, 52425 Jülich, Germany, Institut für Molekulare Biotechnologie Beutenbergstrasse 11, 07745 Jena, Germany Max-Planck-Institut für Biochemie Am Klopferspitz 18, 82152 Martinsried, Germany Friedrich-Schiller-Universität Institut für Neuropathologie, 07743 Jena, Germany Institut für Physikalische Biologie Heinrich-Heine-Universität, 40225 Düsseldorf, Germany Istituto di Biostrutture e Bioimmagini Via Mezzocannone 6/8, 80134 Naples, Italy (literal)

Titolo

• Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Ab1-42 by mirror image phage display. (literal)

Abstract

• A mirror image phage display approach was used to identify novel and highly specific ligands for Alzheimer's disease amyloid peptide Ab(1-42). A randomized 12-mer peptide library presented on M13 phages was screened for peptides with binding affinity for the mirror image of Ab(1-42). After four rounds of selection and amplification the peptides were enriched with a dominating consensus sequence. The mirror image of the most representative peptide (D-pep) was shown to bind Ab(1-42) with a dissocn. const. in the submicromolar range. Furthermore, in brain tissue sections derived from patients that suffered from Alzheimer's disease, amyloid plaques and leptomeningeal vessels contg. Ab amyloid were stained specifically with a fluorescence-labeled deriv. of D-pep. Fibrillar deposits derived from other amyloidosis were not labeled by D-pep. Possible applications of this novel and highly specific Ab ligand in diagnosis and therapy of Alzheimer's disease are discussed. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• ENRICO BUCCI (Persona)

Insieme di parole chiave

• Keywords of "Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Ab1-42 by mirror image phage display." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR di

• ENRICO BUCCI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ChemBioChem (Rivista)

Insieme di parole chiave di

• Keywords of "Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Ab1-42 by mirror image phage display." (Insieme di parole chiave)