http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13452
Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression. (Articolo in rivista)
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- Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression. (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Bashan, Anat; Agmon, Ilana; Zarivach, Raz; Schluenzen, Frank; Harms, Joerg; Berisio, Rita; Bartels, Heike; Franceschi, Francois; Auerbach, Tamar; Hansen, Harly A. S.; Kossoy, Elizaveta; Kessler, Maggie; Yonath, Ada. (2003)
Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression.
in Molecular cell
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- Bashan, Anat; Agmon, Ilana; Zarivach, Raz; Schluenzen, Frank; Harms, Joerg; Berisio, Rita; Bartels, Heike; Franceschi, Francois; Auerbach, Tamar; Hansen, Harly A. S.; Kossoy, Elizaveta; Kessler, Maggie; Yonath, Ada. (literal)
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- Titolo
- Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression. (literal)
- Abstract
- Crystal structures of tRNA mimics complexed with the large ribosomal subunit of Deinococcus radiodurans indicate that remote interactions det. the precise orientation of tRNA in the peptidyl-transferase center (PTC). The PTC tolerates various orientations of puromycin derivs. and its flexibility allows the conformational rearrangements required for peptide-bond formation. Sparsomycin binds to A2602 and alters the PTC conformation. H69, the intersubunit-bridge connecting the PTC and decoding site, may also participate in tRNA placement and translocation. A spiral rotation of the 3' end of the A-site tRNA around a 2-fold axis of symmetry identified within the PTC suggests a unified ribosomal machinery for peptide-bond formation, A-to-P-site translocation, and entrance of nascent proteins into the exit tunnel. Similar 2-fold related regions, detected in all known structures of large ribosomal subunits, indicate the universality of this mechanism. (literal)
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