Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.febslet.2004.03.065 (literal)

Alternative label

• Agmon, Ilana; Amit, Maya; Auerbach, Tamar; Bashan, Anat; Baram, David; Bartels, Heike; Berisio, Rita; Greenberg, Inbal; Harms, Joerg; Hansen, Harly A. S.; Kessler, Maggie; Pyetan, Erez; Schluenzen, Frank; Sittner, Assa; Yonath, Ada; Zarivach, Raz. (2004)
  Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism.
  in FEBS letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Agmon, Ilana; Amit, Maya; Auerbach, Tamar; Bashan, Anat; Baram, David; Bartels, Heike; Berisio, Rita; Greenberg, Inbal; Harms, Joerg; Hansen, Harly A. S.; Kessler, Maggie; Pyetan, Erez; Schluenzen, Frank; Sittner, Assa; Yonath, Ada; Zarivach, Raz. (literal)

Pagina inizio

• 20 (literal)

Pagina fine

• 25 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 567 (literal)

Rivista

• FEBS letters (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Agmon, Ilana; Amit, Maya; Auerbach, Tamar; Bashan, Anat; Baram, David; Greenberg, Inbal; Kessler, Maggie; Pyetan, Erez; Sittner, Assa : The Weizmann Institute, 76100 Rehovot, Israel Bartels, Heike; Harms, Joerg; Hansen, Harly A. S.; Schluenzen, Frank; Yonath, Ada; Zarivach, Raz: Max Planck Institute, Hamburg, Germany. Berisio, Rita; IBB CNR (literal)

Titolo

• Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism. (literal)

Abstract

• The linkage between internal ribosomal symmetry and tRNA (tRNA) positioning confirmed positional catalysis of amino-acid polymn. Peptide bonds are formed concurrently with tRNA-3'end rotatory motion, in conjunction with the overall mRNA (mRNA)/tRNA translocation. Accurate substrate alignment, mandatory for the processivity of protein biosynthesis, is governed by remote interactions. Inherent flexibility of a conserved nucleotide, anchoring the rotatory motion, facilitates chirality discrimination and antibiotics synergism. Potential tRNA interactions explain the universality of the tRNA CCA-end and P-site preference of initial tRNA. The interactions of protein L2 tail with the symmetry-related region periphery explain its conservation and its contributions to nascent chain elongation. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• RITA BERISIO (Persona)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR di

• RITA BERISIO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• FEBS letters (Rivista)