A novel MLL/AF4 fusion gene lacking the AF4 transactivating domain in infant acute lymphoblastic leukemia. (Articolo in rivista)

Type
Label
  • A novel MLL/AF4 fusion gene lacking the AF4 transactivating domain in infant acute lymphoblastic leukemia. (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pane F., Intrieri M., Izzo B., Quintarelli C., Vitale D., Migliorati R., Sebastio L., Salvatore F. (2002)
    A novel MLL/AF4 fusion gene lacking the AF4 transactivating domain in infant acute lymphoblastic leukemia.
    in Blood
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pane F., Intrieri M., Izzo B., Quintarelli C., Vitale D., Migliorati R., Sebastio L., Salvatore F. (literal)
Pagina inizio
  • 4247 (literal)
Pagina fine
  • 4248 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 100 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • A novel MLL/AF4 fusion gene lacking the AF4 transactivating domain in infant acute lymphoblastic leukemia. (literal)
Abstract
  • Southern anal. of the MLL Locus in DNA from bone marrow cells samples from a 5-mo old child with acute lymphoblastic leukemiasampled at diagnosis revealed a rearrangement at locus MLL of chromosome 11q23. Panhandle PCR amplification of the fragment comprising the der(11) translocation breakpoints yielded a 4.6 kb fragment corresponding to the bamHI-rearranged fragment detected by Southern anal. The new fusion gene lacks both the AF4-derived and the MLL-derived (nucleotide 2772-3579) transactivating domain. The resulting fusion protein is able to bind DNA through the MLL-derived AT hook domain, and through the AF4-derived nuclear targeting sequence domain but could lose its capacity to activate the expression of these genes. (literal)
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