Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Meyer Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF (2002)
  Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia
  in Nature neuroscience (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Meyer Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF (literal)

Pagina inizio

• 267 (literal)

Pagina fine

• 271 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3-May (literal)

Rivista

• Nature neuroscience (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Unit on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, 10-4C101, 9000 Rockville Pike, Bethesda, Maryland 20892-1365, USA National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20832, USA PET Department, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20832, USA Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20832, USA (literal)

Titolo

• Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (literal)

Abstract

• Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic function simultaneously with regional cerebral blood flow during the Wisconsin Card Sorting Test (WCST) and a control task in unmedicated schizophrenic subjects and matched controls. We show that the dopaminergic uptake constant Ki in the striatum was significantly higher for patients than for controls. Patients had significantly less WCST-related activation in PFC. The two parameters were strongly linked in patients, but not controls. The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• MARIO QUARANTELLI (Persona)

Incoming links:

Autore CNR di

• MARIO QUARANTELLI (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature neuroscience (Rivista)