Analysis of UTRs from nuclear-encoded mRNA targeting the mitochondrion in Metazoa reveals new insights about molecular mechanisms controlling mitochondrial biogenesis (Abstract/Poster in atti di convegno)

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  • Analysis of UTRs from nuclear-encoded mRNA targeting the mitochondrion in Metazoa reveals new insights about molecular mechanisms controlling mitochondrial biogenesis (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • D’Elia Domenica , Germinario Lucrezia , Grillo Giorgio (2007)
    Analysis of UTRs from nuclear-encoded mRNA targeting the mitochondrion in Metazoa reveals new insights about molecular mechanisms controlling mitochondrial biogenesis
    in BITS2007 Meeting, Napoli
    (literal)
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  • D’Elia Domenica , Germinario Lucrezia , Grillo Giorgio (literal)
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  • The structural analyses of UTR sequences investigated have revealed a significant contraction of their average length when compared with values obtained on total cell mRNAs, with a much more marked effect in 5UTRs. We have also found IRESs motifs in the 3UTRs of respiratory genes in human and rodents, as reported in literature, and also in B. taurus, D. rerio and D. melanogaster and in the 3UTRs of mtTFA and EF-Tu mitochondrial factors, in human and others mammals. On the whole these findings suggest that the translational molecular mechanism controlling mitochondrial differentiation is common not only to mammals, but also to other taxonomic groups, and that the coordination of nucleus-mitochondrion expression during the development is mediated at the translation level by IRESs. The importance of translation control on mitochondrial biogenesis and function has been further underlined by results obtained from our analyses on transcripts that incorporate at their 5’ terminus TOP motifs and of INS_SCE motifs in the 3UTRs of respiratory genes mRNAs. INS_SCE has a key role in the stabilization of insulin transcript, a key modulator of insulin production. Our findings suggest a potential coordinated control of insulin secretion and mitochondrial biogenesis that could shed light on the still unknown mechanisms controlling the functional interdependence among glucose-dependent insulin secretion, mitochondrial biogenesis and insulin-mitochondria dependent myogenesis. (literal)
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  • Regulated translation of mRNA controls a wide range of processes in eukaryote and is mainly mediated by mRNA untranslated regions (UTRs). The present work represents the first large scale analysis carried out on UTRs of nucleus-encoded mitochondrial mRNA in Metazoa. The analysis has been focused on the investigation of UTRs structural and functional features and has been carried out using three reference databases: MitoRes, UTRdb and UTRsite. The aim of this study was to use UTRs analysis to investigate the role of translational control in coordinated expression of nuclear and mitochondrial genomes in mitochondrial biogenesis and function. The results obtained highlight interesting and unknown features, underlining the importance of translational control in the coordination of mitochondrial biogenesis programme during cell growth, differentiation and in response to environmental stimuli. (literal)
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  • CNR - Istituto di Tecnologie Biomediche - sede di Bari (literal)
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  • Analysis of UTRs from nuclear-encoded mRNA targeting the mitochondrion in Metazoa reveals new insights about molecular mechanisms controlling mitochondrial biogenesis (literal)
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