Aquaporin-8- facilitated mitochondrial ammonia transport. (Articolo in rivista)

Type
Label
  • Aquaporin-8- facilitated mitochondrial ammonia transport. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbrc.2010.01.104 (literal)
Alternative label
  • Soria LR, Fanelli E, Altamura N, Svelto M, Marinelli RA, Calamita G. Altamura N, Svelto M, Marinelli RA, Calamita G. (2010)
    Aquaporin-8- facilitated mitochondrial ammonia transport.
    in Biochemical and biophysical research communications (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Soria LR, Fanelli E, Altamura N, Svelto M, Marinelli RA, Calamita G. Altamura N, Svelto M, Marinelli RA, Calamita G. (literal)
Pagina inizio
  • 217 (literal)
Pagina fine
  • 221 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://scholar.google.it/citations?view_op=view_citation&hl=en&user=woHO9DIAAAAJ&citation_for_view=woHO9DIAAAAJ:UeHWp8X0CEIC (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 393 (literal)
Rivista
Note
  • Google Schol (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Instituto de Fisiología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Santa Fe, Argentina b Dipartimento di Fisiologia Generale ed Ambientale, Università degli Studi di Bari ''Aldo Moro\", Bari, Italy c Consiglio Nazionale delle Ricerche, Istituto di Biomembrane e Bioenergetica, Bari, Italy (literal)
Titolo
  • Aquaporin-8- facilitated mitochondrial ammonia transport. (literal)
Abstract
  • Aquaporin-8 (AQP8) is a membrane channel permeable to water and ammonia. As AQP8 is expressed in the inner mitochondrial membrane of several mammalian tissues, we studied the effect of the AQP8 expression on the mitochondrial transport of ammonia. Recombinant rat AQP8 was expressed in the yeast Saccharomyces cerevisiae. The presence of AQP8 in the inner membrane of yeast mitochondria was demonstrated by subcellular fractionation and immunoblotting analysis. The ammonia transport was determined in isolated mitochondria by stopped flow light scattering using formamide as ammonia analog. We found that the presence of AQP8 increased by threefold mitochondrial formamide transport. AQP8-facilitated mitochondrial formamide transport in rat native tissue was confirmed in liver (a mitochondrial AQP8-expressing tissue) vs. brain (a mitochondrial AQP8 non-expressing tissue). Comparative studies indicated that the AQP8-mediated mitochondrial movement of formamide was markedly higher than that of water. Together, our data suggest that ammonia diffusional transport is a major function for mitochondrial AQP8. (literal)
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