The PGC-1a-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer (Articolo in rivista)

Type
Label
  • The PGC-1a-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbrc.2009.10.114 (literal)
Alternative label
  • Cormio A;, Guerra F; Cormio G; Pesce V; Fracasso F; Loizzi V; Cantatore P; Selvaggi L; Gadaleta MN. (2009)
    The PGC-1a-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer
    in Biochemical and biophysical research communications (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cormio A;, Guerra F; Cormio G; Pesce V; Fracasso F; Loizzi V; Cantatore P; Selvaggi L; Gadaleta MN. (literal)
Pagina inizio
  • 1182 (literal)
Pagina fine
  • 1185 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 390 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 4 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a) Department of Biochemistry and Molecular Biology “E. Quagliariello”, University of Bari, Via Orabona, 4-70126 Bari, Italy b) Department of Gynecology, Obstetrics and Neonatology, University of Bari, Piazza Giulio Cesare, 11-70124 Bari, Italy c) Institute of Biomembranes e Bioenergetics CNR, Via Amendola, 165/A-70126 Bari, Italy 4) Centro di Eccellenza di Genomica in Campo Biomedico ed Agrario, University of Bari, Italy (literal)
Titolo
  • The PGC-1a-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer (literal)
Abstract
  • PGC-1alpha-dependent pathway of mitochondrial biogenesis was investigated for the first time in type I endometrial cancer and in normal endometrium. In cancer endometrial tissue the citrate synthase activity, the mitochondrial DNA content and the TFAM level were found doubled compared to control endometrial tissue. Moreover, a 1.6- and 1.8-fold increase, respectively, of NRF-1 and PGG-1alpha expression was found. This study demonstrates, for the first time, that the increased mitochondrial biogenesis in type I endometrial cancer is associated to the upregulation of PGC-1alpha signalling pathway. (literal)
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