Localization of Abasic Sites and Single-Strand Breaks in Mitochondrial DNA from Brain of Aged Rat, Treated or not with Caloric Restriction Diet (Articolo in rivista)

Type
Label
  • Localization of Abasic Sites and Single-Strand Breaks in Mitochondrial DNA from Brain of Aged Rat, Treated or not with Caloric Restriction Diet (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Lezza AM, Fallacara FP, Pesce V, Leeuwenburgh C, Cantatore P, Gadaleta MN (2008)
    Localization of Abasic Sites and Single-Strand Breaks in Mitochondrial DNA from Brain of Aged Rat, Treated or not with Caloric Restriction Diet
    in Neurochemical research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lezza AM, Fallacara FP, Pesce V, Leeuwenburgh C, Cantatore P, Gadaleta MN (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Localization of Abasic Sites and Single-Strand Breaks in Mitochondrial DNA from Brain of Aged Rat, Treated or not with Caloric Restriction Diet (literal)
Abstract
  • According to the \"mitochondrial theory of aging\" the lifelong accumulation of various kinds of damage to mitochondrial DNA (mtDNA) has been related to the age-dependent mitochondrial bioenergetic dysfunction. Caloric restriction (CR) diet is able to prevent or delay the onset of several age-related damages to mtDNA. The effects of aging and CR on the presence of abasic sites and single-strand breaks of the sugar-phosphate backbone in mtDNA have been analyzed by applying Ligation Mediated-PCR to a H strand region of brain mtDNA from young and old ad libitum-fed and old CR-treated rats. The region, encompassing the Direct Repeat 1 of the 4,834 bp-long deletion, is highly damaged in the old ad libitum-fed animals with respect to the young ones, whereas in the CR rats it shows a much lower extent of damage. The data confirm, at single nucleotide resolution, the protective effect of CR on the age-related mtDNA damage (literal)
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