Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Sergio Papa, Domenico De Rasmo, Salvatore Scacco, Anna Signorile, Zuzana Technikova-Dobrova, Giuseppe Palmisano, Anna Maria Sardanelli, Francesco Papa, Damiano Panelli, Raffaella Scaringi and Arcangela Santeramo (2008)
  Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sergio Papa, Domenico De Rasmo, Salvatore Scacco, Anna Signorile, Zuzana Technikova-Dobrova, Giuseppe Palmisano, Anna Maria Sardanelli, Francesco Papa, Damiano Panelli, Raffaella Scaringi and Arcangela Santeramo (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Medical Biochemistry, Biology and Physics (DIBIFIM), University of Bari, Italy Institute of Biomembranes and Bioenergetics (IBBE), Consiglio Nazionale delle Ricerche, Italy Department of Odontostomatology and Surgery, University of Bari, Bari, Italy Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic (literal)

Titolo

• Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function (literal)

Abstract

• In this paper the regulatory features of complex I of mammalian and human mitochondria are reviewed. In a variety of mitotic cell-line cultures, activation in vivo of the cAMP cascade, or direct addition of cAMP, promotes the NADH–ubiquinone oxidoreductase activity of complex I and lower the cellular level of ROS. These effects of cAMP are found to be associated with PKA-mediated serine phosphorylation in the conserved C-terminus of the subunit of complex I encoded by the nuclear gene NDUFS4. PKA mediated phosphorylation of this Ser in the C-terminus of the protein promotes its mitochondrial import and maturation. Mass-spectrometry analysis of the phosphorylation pattern of complex I subunits is also reviewed. (literal)

Prodotto di

• Sistemi boenergetici di membrana: meccanismi funzionali e fisiopatologia. (SV.P14.005.001) (Modulo)
• Institute of biomembrane and bioenergetics (IBBE) (Istituto)

Autore CNR

• SERGIO PAPA (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomembrane and bioenergetics (IBBE) (Istituto)
• Sistemi boenergetici di membrana: meccanismi funzionali e fisiopatologia. (SV.P14.005.001) (Modulo)

Autore CNR di

• SERGIO PAPA (Unità di personale esterno)

Insieme di parole chiave di

• Keywords of "Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function" (Insieme di parole chiave)