http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12839
The inhibitory binding site(s) of Zn2+ in cytochrome c oxidase (Articolo in rivista)
- Type
- Label
- The inhibitory binding site(s) of Zn2+ in cytochrome c oxidase (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Alternative label
Francesco Francia, Lisa Giachini, Federico Boscherini, Giovanni Venturoli, Giuseppe Capitanio, Pietro Luca Martino and Sergio Papa (2007)
The inhibitory binding site(s) of Zn2+ in cytochrome c oxidase
in FEBS letters (Print)
(literal)
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- Francesco Francia, Lisa Giachini, Federico Boscherini, Giovanni Venturoli, Giuseppe Capitanio, Pietro Luca Martino and Sergio Papa (literal)
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- ISI Web of Science (WOS) (literal)
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- Department of Biology, University of Bologna, Bologna, Italy
Department of Physics, University of Bologna, Bologna, Italy
Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia (CNISM), Bologna, Italy
Department of Medical Biochemistry, Biology and Physics, University of Bari, Policlinico, P.zza G. Cesare, 70124 Bari, Italy
Institute of Bioenergetics and Biomembranes, CNR, Bari, Italy
(literal)
- Titolo
- The inhibitory binding site(s) of Zn2+ in cytochrome c oxidase (literal)
- Abstract
- EXAFS analysis of Zn binding site(s) in bovine-heart cytochrome c oxidase and characterization of the inhibitory effect of internal zinc on respiratory activity and proton pumping of the liposome reconstituted oxidase are presented.
EXAFS identifies tetrahedral coordination site(s) for Zn2+ with two N-histidine imidazoles, one N-histidine imidazol or N-lysine and one OCOOH (glutamate or aspartate), possibly located at the entry site of the proton conducting D pathway in the oxidase and involved in inhibition of the oxygen reduction catalysis and proton pumping by internally trapped zinc.
(literal)
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