cAMP controls oxygen metabolism in mammalian cells. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• cAMP controls oxygen metabolism in mammalian cells. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• C. Piccoli, S. Scacco, F. Bellomo, A. Signorile, A. Iuso, D. Boffoli, R. Scrima, N. Capitanio, S. Papa (2006)
  cAMP controls oxygen metabolism in mammalian cells.
  in FEBS letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• C. Piccoli, S. Scacco, F. Bellomo, A. Signorile, A. Iuso, D. Boffoli, R. Scrima, N. Capitanio, S. Papa (literal)

Pagina inizio

• 4539 (literal)

Pagina fine

• 4543 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 580 (literal)

Rivista

• FEBS letters (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Biomedical Science, University of Foggia, Foggia, Italy Department of Medical Biochemistry, Biology and Physics, University of Bari, Bari, Italy Institute of Bioenergetics and Biomembranes, CNR, Bari, Italy (literal)

Titolo

• cAMP controls oxygen metabolism in mammalian cells. (literal)

Abstract

• The impact of cAMP on ROS-balance in human and mammalian cell cultures was studied. cAMP reduced accumulation of ROS induced by serum-limitation, under conditions in which there was no significant change in the activity of scavenger systems. This effect was associated with cAMP-dependent activation of the NADH-ubiquinone oxidoreductase activity of complex I. In fibroblasts from a patient a genetic defect in the 75 kDa FeS-protein subunit of complex I resulted in inhibition of the activity of the complex and enhanced ROS production, which were reversed by cAMP. A missense genetic defect in the NDUFS4 subunit, putative substrate of PKA, suppressed, on the other hand, the activity of the complex and prevented ROS production. (literal)

Prodotto di

• Institute of biomembrane and bioenergetics (IBBE) (Istituto)
• Sistemi boenergetici di membrana: meccanismi funzionali e fisiopatologia. (SV.P14.005.001) (Modulo)

Autore CNR

• SERGIO PAPA (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of biomembrane and bioenergetics (IBBE) (Istituto)
• Sistemi boenergetici di membrana: meccanismi funzionali e fisiopatologia. (SV.P14.005.001) (Modulo)

Autore CNR di

• SERGIO PAPA (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• FEBS letters (Rivista)