Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content (Articolo in rivista)

Type
Label
  • Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cassano P, Sciancalepore AG, Lezza AM, Leeuwenburgh C, Cantatore P, Gadaleta MN (2006)
    Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content
    in Journal of anti-aging medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cassano P, Sciancalepore AG, Lezza AM, Leeuwenburgh C, Cantatore P, Gadaleta MN (literal)
Pagina inizio
  • 211 (literal)
Pagina fine
  • 214 (literal)
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  • 9 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Pubblicazione scientifica di interesse internazionale (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; Istituto di Biomembrane e Bioenergetica, CNR, Bari, Via Orabona 4, 70125, Bari, Italy (literal)
Titolo
  • Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content (literal)
Abstract
  • The effect of age and caloric-restriction (CR) diet on mitochondrial DNA (mtDNA) content in different rat tissues was investigated. A decrease of the mtDNA content occurs with aging in liver and soleus muscle, whereas there is no age-related significant change of mtDNA content in brain. CR fully reverses the age-dependent loss of mtDNA in liver and soleus, whereas it results in a significant increase of mtDNA amount above the value of aged ad libitum fed rats in brain. These results further support the tissue-specific effect of CR, likely because of the different dependence of tissues on external nutrient uptake. (literal)
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