Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, Languino LR. (2004)
  Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.
  in The Journal of cell biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, Languino LR. (literal)

Pagina inizio

• 407 (literal)

Pagina fine

• 418 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 166 (literal)

Rivista

• ?The ?Journal of cell biology (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IBBE, CNR, Bari, Italy; Cancer Center, University of Massachusetts Medical School, Worcester, USA; Department of Pathology, Yale University School of Medicine, New Haven, USA. (literal)

Titolo

• Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. (literal)

Abstract

• We show here that beta1 integrins selectively modulate insulin-like growth factor type I receptor (IGF-IR) signaling in response to IGF stimulation. The beta1A integrin forms a complex with the IGF-IR and insulin receptor substrate-1 (IRS-1); this complex does not promote IGF-I mediated cell adhesion to laminin (LN), although it does support IGF-mediated cell proliferation. In contrast, beta1C, an integrin cytoplasmic variant, increases cell adhesion to LN in response to IGF-I and its down-regulation by a ribozyme prevents IGF-mediated adhesion to LN. Moreover, beta1C completely prevents IGF-mediated cell proliferation and tumor growth by inhibiting IGF-IR auto-phosphorylation in response to IGF-I stimulation. Evidence is provided that the beta1 cytodomain plays an important role in mediating beta1 integrin association with either IRS-1 or Grb2-associated binder1 (Gab1)/SH2-containing protein-tyrosine phosphate 2 (Shp2), downstream effectors of IGF-IR: specifically, beta1A associates with IRS-1 and beta1C with Gab1/Shp2. This study unravels a novel mechanism mediated by the integrin cytoplasmic domain that differentially regulates cell adhesion to LN and cell proliferation in response to IGF. (literal)

Prodotto di

• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)
• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR

• LOREDANA MORO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)

Autore CNR di

• LOREDANA MORO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?Journal of cell biology (Rivista)

Insieme di parole chiave di

• Keywords of "Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins." (Insieme di parole chiave)