Ceramide Induces Release of Pro-Apoptotic Proteins from Mitochondria by Either a Ca2+-Dependent or a Ca2+-Independent Mechanism (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Ceramide Induces Release of Pro-Apoptotic Proteins from Mitochondria by Either a Ca2+-Dependent or a Ca2+-Independent Mechanism (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Di Paola M.; Zaccagnino P.; Montedoro G.; Cocco T.; Lorusso M. (2004)
  Ceramide Induces Release of Pro-Apoptotic Proteins from Mitochondria by Either a Ca2+-Dependent or a Ca2+-Independent Mechanism
  in Journal of bioenergetics and biomembranes
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Di Paola M.; Zaccagnino P.; Montedoro G.; Cocco T.; Lorusso M. (literal)

Pagina inizio

• 165 (literal)

Pagina fine

• 170 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 36 (literal)

Rivista

• Journal of bioenergetics and biomembranes (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Biomembranes and Bioenergetics, CNR, Bari, Italy; Department of Medical Biochemistry and Biology, University of Bari, Bari, Italy (literal)

Titolo

• Ceramide Induces Release of Pro-Apoptotic Proteins from Mitochondria by Either a Ca2+-Dependent or a Ca2+-Independent Mechanism (literal)

Abstract

• Several observations have been reported in the last years indicating that ceramide may activate the mitochondrial route of apoptosis. We show here that on addition of either C2- or C16-ceramide to mitochondria isolated from rat heart and suspended in a saline medium, release of cytochrome c and apoptosis-inducing factor (AIF) from the intermembrane space takes place. The release process is Ca2+-independent and is not inhibited by Cyclosporin A (CsA). For the protein release process to occur, the presence of an oxidizable substrate is required. When mitochondria are suspended in sucrose instead of potassium medium, only short chain C2-ceramide causes cytochrome c release through a Ca2+-dependent and CsA sensitive mitochondrial permeability transition (MPT) mechanism. The latter effect appears to be related to the membrane potential dissipating ability exhibited by short chain C2-ceramide. (literal)

Prodotto di

• Institute of biomembrane and bioenergetics (IBBE) (Istituto)

Autore CNR

• MARCO DI PAOLA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Ceramide Induces Release of Pro-Apoptotic Proteins from Mitochondria by Either a Ca2+-Dependent or a Ca2+-Independent Mechanism" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomembrane and bioenergetics (IBBE) (Istituto)

Autore CNR di

• MARCO DI PAOLA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of bioenergetics and biomembranes (Rivista)

Insieme di parole chiave di

• Parole chiave di "Ceramide Induces Release of Pro-Apoptotic Proteins from Mitochondria by Either a Ca2+-Dependent or a Ca2+-Independent Mechanism" (Insieme di parole chiave)